钯催化合成2-(2,4-二氟苯基)吡啶

Synthesis of 2-(2,4-Difluorophenyl)pyridine by Palladium-catalyzed

以Pd(OAc)2为主催化剂,PPh3为配体,2-溴(氯)吡啶和2,4-二氟苯硼酸通过Suzuki偶联反应合成了2-(2,4-二氟苯基)吡啶,产率>90%,其结构经1H NMR,19FNMR和IR确证。

2-（2,4-Difluorophenyl）pyridine in yield over 90% was synthesized by Suzuki cross-coupling reaction of 2-bromo（or chloro）pyridine with 2,4-difluorophenylboronic in the presence of catalyst system of Pd（OAc）2/PPh3.The structure was confirmed by 1H NMR,19F NMR and IR.