摘要
对DNA编码约束进行研究,选择汉明测量以及相似度作为DNA序列集设计的主要约束,并结合连续性约束与GC Content约束,将序列集设计问题抽象为带有强约束的多目标优化问题,采用文化微粒群算法解决该多目标优化问题。仿真结果表明,该混合算法针对DNA编码序列设计问题,在求解最优值能力、解的稳定性方面都能取得较好的效果。
DNA encoding constrained is researched. H-measure and similarity is the principal constrained for DNA sequence design. Continuity and GC Content is also another constrained. DNA sequence design is presented to solve the multi-objective optimization problem. Particle Swarm Optimization based on Cultural Algorithm(PSO-CA) is proposed to solve the DNA sequence design as a multi-objective optimization problem. Simulation results indicate the hybrid algorithm does well on searching efficiency and key stability for DNA sequence design problem.
出处
《计算机工程》
CAS
CSCD
北大核心
2011年第3期10-12,共3页
Computer Engineering
基金
国家自然科学基金资助项目(60903188)
上海市高校选拔培养优秀青年教师科研专项基金资助项目(sdl-07013)
高等学校博士点基金资助项目(20093120110008)
上海市重点学科建设基金资助项目(S30504)
关键词
微粒群优化算法
文化演化
DNA编码
汉明测量
Particle Swarm Optimization(PSO) algorithm
cultural evolution
DNA encoding
H-measure