耳穴贴压王不留行籽对原发性高血压的治疗作用以及对患者血浆生化值的影响

The Effect of Ear Acuppoint on Essential Hypertention and Biochemic

目的:旨在采用耳穴帖压王不留行籽治疗经生活干预无效,其血压处于原发性高血压1级的患者,监测治疗前后患者的血压变化,以及血浆中肾素(Renin,Ren)、血管紧张素Ⅱ(AngiotensinⅡ,ATⅡ)、总胆固醇(TC)、甘油三酯(TG)含量的变化,探讨耳穴降压的生理机制。方法:本研究为随机、对照设计,选择治疗组、对照组各60例患者,治疗组进行耳穴贴压治疗,对照组服用硝苯地平控释片治疗(30mg/d),观察21天,每日监测血压情况,测定治疗前后血浆肾素和血管紧张素Ⅱ、胆固醇(TC)、甘油三酯(TG)含量的变化。结果:①两组血压控制有效率无显著差异(P>0.05)。②治疗组、对照组两组临床症状疗效差异无显著性(P>0.05)。③治疗组能使总胆固醇(TC)、甘油三酯(TG)显著降低(P<0.05);对照组治疗前后总胆固醇(TC)、甘油三酯(TG)检测结果无显著差异(P>0.05)。④治疗前后两组Ren、ATⅡ测定结果对比:治疗后,治疗组Ren含量无显著变化(P>0.05),治疗组ATⅡ有所降低(P<0.05);对照组Ren、ATⅡ含量均无显著变化(P>0.05)。结论:耳穴贴压与口服硝苯地平控释片治疗EH,均可有效控制血压在正常范围;治疗组与对照组均能显著改善患者临床症状;治疗组能使TC、TG有所降低,对照组则对TC、TG含量无显著影响;两组治疗后对肾素含量均无显著影响;治疗组治疗后可使血管紧张素Ⅱ含量有所降低,对照组治疗后对血管紧张素Ⅱ含量无显著影响。

Objective：The purpose of this study is to treat the patients with EH stage 1 who have not improved through lifestyle modification using Wangbuliuxing.The patients’ renin（REN）,angiotensinⅡ（ATⅡ）,total cholesterol（TC）,triglyceride（TG） were monitored before and after the treatment.The blood-reducing mechanism of Auricular buck was disccused.Methods：This study was a randomized and controlled design in accordasnce with the diagnostic criteria and inclusion standard.120 patients were randomly selected into two groups,treatment group and control group.Each group contains 60 patients.The treatment group was given Auricular post plaster with Wangbuliuxing,the control group was given nifedifine GITS（30 mg/day）,lasting 21 days.Daily blood pressure was taken and REN,ATⅡ,TC and TG were monitored before and after the treatment.Results：①Blood pressure control efficiency is no statistically significant difference between these two groups（P〉0.05）.②The curative effect after treatment is no statistically significant difference in curative effect between these two groups（P〉0.05）.③Changes in blood pressure after treatment are statistically significant difference in the range of decline between these two groups（P〉0.05）.④Comparing symptom scores before and after treatment： in both the treatment group and the control group the points after treatment significantly decreased（P〈0.05）;after treatment the points in the treatment group decreased much more than the control group（P〈0.05）.⑤TG and TC in the treatment group significantly decreased after treatment（P〈0.05）;there was no significant change of TG and TC content in the control group before and after treatment（P〉0.05）.⑥in the treatment group there was no significant change in Ren content before and after treatment（P〉0.05）,there was a significant decrease in ATⅡcontent（P〈0.05）;in the control group there were not a significant decrease in both REN and ATⅡcontents（P〉0.05）.Conclusion：Both Ear point-pressure and oral nifedifine can control the blood pressure of patients with EH in the normal range;both treatment group and control group can lighten the patients’ symptoms;the treatment group reduces TC and TG,control group has no significant influence on TC and TG.both groups have not a noticeable influence on Ren;the treatment group decreases ATⅡcontent,while the control group has no significant influence on ATⅡcontent.