诺和锐30治疗2型糖尿病疗效观察

Curative effects observation of insulin aspart 30 injection in treatment of type 2 diabetes

目的:观察诺和锐30和诺和灵30R治疗2型糖尿病的临床疗效。方法:60例2型糖尿病患者随机分成诺和锐30组和诺和灵30R组,12周后观察两种不同治疗方案患者血糖达标时间、空腹血糖、餐后2小时血糖、糖化血红蛋白A1(HbA1c)、胰岛素日用量及低血糖发生的情况。结果:诺和锐30组餐后血糖较诺和灵30R组下降更明显(P<0.01);两组患者空腹静脉血糖及糖化血红蛋白差异无统计学意义(P>0.05);治疗后两组胰岛素用量差异无统计学意义(P>0.05);体质量指数(P>0.05);诺和锐30组低血糖发生率显著低于诺和灵30R组(P<0.05)。结论:诺和锐30降血糖快,不良反应少,是治疗2型糖尿病较理想类型的胰岛素制剂。

To evaluate the effect of insulin aspart 30 injection and novolin 30R prnfill in the treatment of type 2 diabetes mellitus （T2DM）.Methods：Sixty patients with T2DM were randomly divided into two groups： insulin aspart 30 injection group and novolin 30R prnfill group.After 12 weeks,the levels of fasting plasma glucose （FBG）,2 h postprandial glucose （2 hPBG）, glycosylated hemoglobin Alc （HbAlc）,body mass index （BMI）,insulin dosages, frequency of hypoglycemia were compared before and after treatment. Results ：2hPBG in the insulin aspart 30 injection group was significantly decreased than that in the novolin 30R prnfill group （P〈0.01）; FBG, HbAlc, BMI and insulin dosages were not significantly different between the two groups （P〉0.05）.The frequency of hypoglycemia in the insulin aspart 30 injection group was significantly lower than that of the novolin 30R prnfill group （P〈0.05）.Conclusion：Insulin aspart 30 injection can effectively decrease 2hPBG and frequency of hypoglycemia in type 2 diabetic patients.