CA153、IL-6及IL-8与乳腺癌骨转移相关性探讨

Study on the correlation between CA153,IL-6,IL-8 levels and bone metastasis in patients with breast cancer

目的探讨糖类抗原153(CA153)及细胞因子[白细胞介素6(IL-6)、白细胞介素8(IL-8)]与乳腺癌骨转移的关系。方法对103例乳腺癌根治手术后患者行单光子发射型(SPECT)骨显像,采用放射免疫法检测血清CA153,放射免疫分析法检测IL-6、IL-8水平,与健康对照组(36例)进行对比分析。结果骨转移组患者血清CA153、IL-6、IL-8水平明显升高,与无骨转移组及健康对照组比较差异均有统计学意义(P<0.05);无骨转移组CA153、IL-6、IL-8水平与健康对照组比较,差异无统计学意义(P>0.05)。结论 CA153对于预测乳腺癌骨转移、筛选行全身骨显像患者具有重要意义;IL-6、IL-8参与乳腺癌骨转移的发生和发展过程,检测IL-6、IL-8对于乳腺癌骨转移的病理研究和预防、治疗可能具有重要价值。

Objective To investigate the corelation of CA153,IL-6,IL-8 and breast cancer bone metastasis.Methods 103 breast cancer patients after radical surgery were scanned by single photon emission computer tomography（SPECT）.Immunoradiometric assay（IRMA） method was used to assay the serum level of CA153,and radioimmunoassay（RIA） method was used to assay serum level of IL-6,IL-8;At the same time,the result was analyzed against the control group of 36 normal people.Results In breast cancer patients group with bone metastasis,the serum level of CA153,IL-6,IL-8 were significantly higher than normal people（P0.05）,while the serum level of CA153,IL-6 and IL-8 in cancer patients group without bone metastasis and in control group were not statistically significant different（P0.05）.Conclusion CA153 has great significance in predicting breast cancer bone metastasis and screening whole body bone imaging;IL-6,IL-8 is engaging in the occurrence and development of bone metastasis,assaying the serum levels of IL-6,IL-8 are of great value to pathology research,prevention and treatment of breast cancer bone metastasis.