摘要
目的检测血管内皮生长因子-C(VEGF-C)在人直肠癌组织和淋巴结中的表达,探讨VEGF-C在人直肠癌发生、发展和淋巴结转移中的作用。方法选择31例手术切除并经病理切片检查确诊为直肠癌患者的癌组织及其中14例淋巴结石蜡标本,采用免疫组织化学方法检测VEGF-C在癌组织和淋巴结内的表达。结果在31例直肠癌组织的癌细胞质中,VEGF-C显色阳性17例,占54.8%;在14例淋巴结中,VEGF-C显色阳性10例,占71.4%。结论 VEGF-C在直肠癌组织和淋巴结中均有较高表达,可能在促使淋巴管内皮细胞增殖、迁移并形成新的淋巴管,导致癌细胞转移过程中起重要作用。
Objective To study the expression of vascular endothelial growth factor-C(VEGF-C) in rectal adenocarcinoma tissue and lymph nodes,and to determine the function of VEGF-C in the process of occurrences,development and lymphatic metastasis of rectal adenocarcinoma.Methods The expression of VEGF-C was detected in 31 paraffin-embedded cases of rectal adenocarcinoma tissue and 14 paraffin-embedded cases of lymph nodes using immunohistochemistry method.Results In plasma of cancer cell of 31 cases of rectal adenocarcinoma,VEGF-C positive expression was detected in 17 cases,the positive rate is 54.8%.In 14 cases of lymph nodes,VEGF-C positive expression was detected in 10 cases,the positive rate is 71.4%.Conclusion The positive rate of VEGF-C are high both in rectal adenocarcinoma and in lymph nodes.VEGF-C can promote proliferation and migration of lymphatic endothelial cells and formation of new lymphatic vessels which plays an important role in metastasis of cancer cells.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第5期425-426,429,F0003,共4页
Chongqing medicine
基金
泸州医学院青年基金资助项目(436)
关键词
血管内皮生长因子-C
免疫组织化学
直肠腺癌
vascular endothelial growth factor-C
immunohistochemistry
rectal adenocarcinoma