人直肠癌血管内皮生长因子-C的表达及其意义

Expression and significance of VEGF-C in rectal adenocarcinoma of human

目的检测血管内皮生长因子-C(VEGF-C)在人直肠癌组织和淋巴结中的表达,探讨VEGF-C在人直肠癌发生、发展和淋巴结转移中的作用。方法选择31例手术切除并经病理切片检查确诊为直肠癌患者的癌组织及其中14例淋巴结石蜡标本,采用免疫组织化学方法检测VEGF-C在癌组织和淋巴结内的表达。结果在31例直肠癌组织的癌细胞质中,VEGF-C显色阳性17例,占54.8%;在14例淋巴结中,VEGF-C显色阳性10例,占71.4%。结论 VEGF-C在直肠癌组织和淋巴结中均有较高表达,可能在促使淋巴管内皮细胞增殖、迁移并形成新的淋巴管,导致癌细胞转移过程中起重要作用。

Objective To study the expression of vascular endothelial growth factor-C（VEGF-C） in rectal adenocarcinoma tissue and lymph nodes,and to determine the function of VEGF-C in the process of occurrences,development and lymphatic metastasis of rectal adenocarcinoma.Methods The expression of VEGF-C was detected in 31 paraffin-embedded cases of rectal adenocarcinoma tissue and 14 paraffin-embedded cases of lymph nodes using immunohistochemistry method.Results In plasma of cancer cell of 31 cases of rectal adenocarcinoma,VEGF-C positive expression was detected in 17 cases,the positive rate is 54.8%.In 14 cases of lymph nodes,VEGF-C positive expression was detected in 10 cases,the positive rate is 71.4%.Conclusion The positive rate of VEGF-C are high both in rectal adenocarcinoma and in lymph nodes.VEGF-C can promote proliferation and migration of lymphatic endothelial cells and formation of new lymphatic vessels which plays an important role in metastasis of cancer cells.