摘要
目的探讨糖尿病合并牙周病与血糖、血脂代谢的关系。方法将54例患者分为3组(A组:无糖尿病的中、重度牙周病患者16例;B组:2型糖尿病且牙周健康患者18例;C组:2型糖尿病合并中、重度牙周病患者20例),并检测TC、TG、LDL-C、HDL-C、空腹血糖(FBG)、糖基化血红蛋白(HbA1c)、高敏C反应蛋白(hsCRP)等。采用牙周治疗需要指数(CPI)评价牙周状况。结果 (1)B、C组患者FBG、TG、TC、LDL-C、HbA1c均明显高于A组(P<0.05)。(2)C组患者牙周袋探诊深度(probingdepth,PD)、牙周附着丧失(attachment loss,AL)均明显高于A组(P<0.01),B组患者PD、AL均明显低于A、C组(P<0.05)。(3)B、C组患者HDL-C均明显低于A组(P<0.05),C组患者HDL-C明显低于B组(P<0.01)。(4)C组患者hsCRP明显高于A、B组(P<0.01),A、B组患者hsCRP比较差异无统计学意义(P>0.05)。(5)CPI与FBG、HbA1c、hsCRP、TC、TG、LDL-C呈正相关(P<0.05、P<0.01),与HDL-C呈负相关(P<0.05、P<0.01)。结论牙周病的严重程度与血糖、TC、TG、LDL-C、HDL-C水平均有关,糖尿病合并牙周病患者更易发生糖脂代谢紊乱。
Objective To investigate the relationship between diabetes mellitus associated periodontal disease and the metabolism of plasma glucose,plasma lipid.Methods 54 subjects in our hospital were divided into 3 groups(A group:16 cases of middle and heavy periodontal disease patients without diabetes mellitus;B group:18 cases of simple type 2 diabetes mellitus patients;C group:20 cases of type 2 diabetes mellitus patients associated middle and heavy periodontal disease).The levels of TC,TG,LDL-C,HDL-C,fasting plasma glucose(FBG),glycosylated hemoglobin(HbA1c),high-sensitive reactive protein C(hs-CRP) were measured:Community periodental index(CPI) of treatment needs was used to evaluate the state of periodontal.Results(1)The FBG,TG,TC,LDL-C and HbA1c were significantly higher in B and C groups than those in A group(P0.05).(2)Probing depth(PD) and attachment loss(AL) were significantly higher in C group than that in A group(P0.01),PD and AL were significantly lower in B group than that in A and C groups(P0.05).(3) The level of HDL-C was higher in B and C groups than that in A group(P0.05).The level of HDL-C was significantly lower in C group than that in B group.(4) The level of hs-CRP was higher in C group than that in A and B groups(P0.01).The level of hs-CRP had no significant difference in A and B groups(P0.05).(5) CPI was positively correlated with FBG,HbA1C,hs-CRP,TC,TG,LDL-C(P0.01).CPI was negatively correlated with HDL-C(P0.01).Conclusion The degree of periodontal disease is significantly and positively correlated with FBG,TG,TC and LDL-C.Patients with diabetes mellitus and periodontal disease are more obtained the disorder metabolism of glucolipid.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第5期443-444,447,共3页
Chongqing medicine
基金
贵州省卫生厅基金资助项目(D-276)
遵义医学院中青年科技基金资助项目(F-185)
关键词
糖尿病
牙周病学
血糖
血脂异常
diabetes mellitas
periodontics
blood glucose
dyslipidemia