匹伐他汀钙治疗62例老年高胆固醇血症的临床观察

Clinical observation of pitavastatin calcium on treatment of 62 elderly hypercholesterolemic patients

目的观察匹伐他汀钙对老年高胆固醇血症患者降脂治疗的有效性和安全性。方法 62例老年高胆固醇血症患者每晚睡前口服匹伐他汀钙,剂量4 mg/d,共6周,观察用药前后总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、肌酸磷酸激酶(CPK)水平变化,以及肝、肾功能情况。结果治疗3周后TC、LDL-C水平均较治疗前显著下降(P<0.01),治疗6周后HDL-C水平较治疗前显著上升(P<0.01),TG水平明显下降(P<0.05),总有效率90.97%。治疗6周后肝、肾功能及CPK无明显变化(P>0.05)。结论匹伐他汀钙对老年高胆固醇血症患者降脂治疗有效且安全,值得临床推广。

Objective To observe the efficacy and safety of pitavastatin calcium in elderly patients with hypercholesterolemia.Methods 62 cases of elderly patients with hypercholesterolemia were gave pitavastatin calcium 4 mg before bedtime for 6 weeks.Before and after treatment,The levels of total cholesterol（TC）,triglyceride（TG）,high density lipoprotein（HDL-C）,low density lipoprotein（LDL-C）,creatine kinase（CPK） were observed and the liver and kidney function were detected.Results After 3 weeks of treatment,the levels of TC,LDL-C were significantly decreased than before treatment（P0.01）.After 6 weeks of treatment,the level of HDL-C was increased significantly（P0.01）,but the level of TG was decreased significantly（P0.05）,total effective rate was 90.97%.After 6 weeks of treatment,the level of CPK,the liver and kidney function had no significant changes（P0.05）.Conclusion Pitavastatin calcium is effective and safe in elderly patients with hypercholesterolemia.