摘要
目的探讨慢性心理应激对大鼠行为及血清白细胞介素2(IL-2)、白细胞介素6(IL-6)、高敏C反应蛋白(hsCRP)的影响。方法利用慢性不可预见的中等强度应激制作大鼠慢性心理应激模型,观察其行为的改变;采用酶联免疫吸附试验法测定其血清IL-2、IL-6和hsCRP的含量。结果应激后大鼠旷场活动性降低(P<0.05),血清IL-2、IL-6和hsCRP含量显著增高(P<0.05)。结论慢性心理应激可以显著影响大鼠的行为和血清炎性因子水平.
Objective To explore the effects of chronic psychological stress on behaviors and serum concentrations of interleukin-2（IL-2）,interleukin-6（IL-6）,high-sensitivity C-reactive protein（hsCRP） in rats.Methods The chronic psychological stress model was mimicked by chronic unpredictable mild stress in rats.The behaviors of rats were observed and the levels of serum IL-2,IL-6 and hsCRP were detected by enzyme-linked immunosorbent assay method.Results After the rats were subjected to chronic unpredictable mild stress stimulus,the stress open-field activity were lower（P0.05）;the levels of serum IL-2,IL-6 and hsCRP were significantly higher in contrast to normal rats（P0.05）.Conclusion Chronic psychological stress can significantly influence the emotional behaviors and serum inflammatory factors levels in rats.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第5期471-472,共2页
Chongqing medicine
