摘要
目的: 探讨早期生长反应基因( Egr1) 在乳腺良性病变和癌组织中的表达及其与乳腺癌的临床病理联系。方法: 用免疫组织化学法对75 例乳腺病变组织进行 Egr1 检测; 观察乳腺良性病变和乳腺癌的表达情况, 并比较其阳性率。结果: 乳腺良性病变可见相对高水平的 Egr1 表达, 而乳腺癌 Egr1 阳性仅19 例(42 .2 % ) ; Egr1 表达与乳腺癌的组织学类型和淋巴结转移有关( P< 0 .05) 。结论: Egr1 表达的减少或消失可作为乳腺肿块恶性变的生物学标志并提示乳腺癌的预后不良。
Objective:To study the expression of early growth response gene 1(Egr 1)in benign breast lesion and cancar tissues and its relation to the clinicopathology of the breast carcinoma. Method:75 cases of different breast lesions were immunohistochemically stained for Egr 1 protein antibody. The positive staining rates of benign breast lesion and breast carcinoma were compared statistically.Result:Benign breast lesion had relatively high level Egr 1 expression and only 19 cases were Egr 1 positive in breast carcinoma. The expression of Egr 1 was related to histological types and to lymphatic metastasis of breast carcer(P<0 05). Conclusion: The decrease or loss of Egr 1 expression might take for biological markers of malignant transformation, and suggesting unfavourable prognosis of breast cancer.
出处
《汕头大学医学院学报》
1999年第2期6-8,共3页
Journal of Shantou University Medical College