肝癌肝硬变患者肝脏胰岛素受体测定

Studies of Liver Insulin Receptors in the Patients with Cirrhosis or Hepatoma

目的 调查肝癌肝硬变患者是否存在肝脏受体性胰岛素抵抗，并为此类病人的营养支持提供理论参考。方法 应用受体放射分析法，对肝癌患者（肝癌组，ｎ＝ １０）肝硬变患者（肝硬变组，ｎ＝ １０）及对照组（ｎ＝ ７）肝癌细胞膜及肝细胞膜的胰岛素受体最大结合位点（Ｂｍ ａｘ）及亲和常数（Ｋｄ）进行了测定，同时测定了血糖及血胰岛素水平。结果 对照组胰岛素受体最大结合位点（Ｂｍ ａｘ：）：２０５．９３±３４．０４（ｆｍｏｌ／ｍｇ 膜蛋白），亲和常数（Ｋｄ）：２．０１±０．７０（１０－ １０ｍ ｏｌ／Ｌ）。血糖为：４．７７±０．４０（ｍｍ ｏｌ／Ｌ），血胰岛素为：８．５７±５．１０（ｍ Ｕ／Ｌ）；肝硬变组胰岛素受体最大结合位点（Ｂｍ ａｘ）：７５．４６±１２．１２（ｆｍ ｏｌ／ｍｇ 膜蛋白），亲和常数（Ｋｄ）为：６．９７±０．９７（１０－ １０ｍ ｏｌ／Ｌ）。血糖为：４．４５±０．５０（ｍ ｍ ｏｌ／Ｌ），血胰岛素为：１８．７０±１０．９０（ｍＵ／Ｌ）；肝癌组胰岛素受体最大结合位点（Ｂｍ ａｘ）：７２．５６±１２．８９：（ｆｍ ｏｌ／ｍｇ 膜蛋白），亲和常数（Ｋｄ）：５．５３±０．８３：（１０－ １０ｍ ｏｌ／Ｌ）。血糖为：４．２８±０．５６（ｍ ｍ ?

? Objective To reveal the relationship between insulin resistance and liver insulin receptor in the patients with cirrhosis or hepatoma.Methods The liver insulin receptor was measured in the patients with cirrhosis or hepatoma.Meanwhile,blood glucose and blood insulin level were determined in all patients by radioreceptor assays.Result The blood insulin level is higher in the both groups of cirrhosis and hepatoma,compared with the control (P<0.05).The Bmaxs of the liver insulin receptors are higher and the Kds of the liver insulin receptors are lower in the groups of cirrhosis and hepatoma,compared with the control (P<0.05).Conclusion The insulin resistance from the liver insulin receptor may exist in the patients with cirrhosis and hepatoma. 〔