羟基喜树碱双途径联合化疗治疗中晚期胃肠癌

Treatment of median and Advanced Gastrointestinal Cancer by Hydroxy Camptothecin intravenous and intraperitoneal Injection

目的 提高中晚期胃肠癌化疗疗效。方法 静脉、腹腔双途径应用羟基喜树碱为主的联合化疗。结果 治疗组有效率６０％ ，对照组有效率４５．５％ ，明显高于对照组，但无统计学差异，Ｐ＞０．０５。生存质量明显提高，人均ｋａｒｎｏｆｓｋｙ评分较对照组提高６．５分。Ｐ＜ ０．０５，有显著性差异。结论 联合羟基喜树碱组成ＥＬＦＯ及ＬＦＯ方案双途径联合化疗对中晚期胃肠癌近期疗效满意。

? Objective To improve the effect of chemotherapy of middle advanced gastrointestinal cancer.Methods Hydroxy camptothecin was combined mainly with other medicine (ELFO or LFO)by intravenous and intraperitoneal injection.Results Effective rate is 60% in treated group,but it is 45% in control group,thedifference was significant,P>0.05,Life quality of treated group was improved,the score of Karnofsky increased 6.5, the differece was significant P<0.05.Conclusion The combined chemotherapy of hydroxy camptothecin (ELFO or LFO) of intravenous and intraperitoneal route is satisfactory in short term for middle and advanced gastrointestinal cancer. 〔