261例艾滋病患者抗病毒治疗疗效分析

Efficacy evaluation of antiviral therapy among 261 AIDS patients

目的评价江西省艾滋病患者接受艾滋病抗病毒治疗前后的疗效,为该地区艾滋病防治提供依据。方法采用整群抽样方法,于2009年7月抽取261例患者,从血象与生化指标上分析抗病毒治疗效果。结果艾滋病患者治疗前后的白细胞、红细胞、血小板、血红蛋白、淋巴细胞绝对值的血象异常率有明显提高(P<0.05),治疗前后的总蛋白、清蛋白、直接胆红素异常率有明显下降(P<0.05),治疗前后的CD4、丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、谷氨酰转肽酶、总胆红素、间接胆红素、血糖、总胆固醇、甘油三酯、尿素氮、肌酐的异常率差异均无统计学意义(P>0.05)。计量结果提示治疗前后CD4、ALT、总蛋白、清蛋白方面的疗效有明显好转(P<0.05)。结论抗病毒治疗疗效在一定程度上较为明显,但多数指标还难以达到正常值水平,因人而异的对症治疗显得尤其必要。

Objective To evaluate the efficacy of highly active antiretroviral therapy for AIDS patients.Methods A cluster sampling method was used for the study.261 patients under AIDS＂cocktail＂ treatment were selected in July 2009.The results of blood and biochemistry testing were analyzed before and after antiviral therapy for the evaluation of treatment efficacy.Results The abnormality proportions of white blood cells,red blood cells,platelets,hemoglobin and absolute lymphocyte increased significantly（P〈0.05）,while the abnormality rates of total protein,albumin and direct bilirubin decreased significantly（P〈0.05） in AIDS patients with treatment.There were no significant differences in the abnormality rates of CD4 cell counts,alanine aminotransferase,aspartate aminotransferase,glutamyl aminopeptidase,total bilirubin,indirect bilirubin,glucose,total cholesterol,triglycerides,urea nitrogen and creatinine.Conclusion The results showed the improvement of CD4 cell counts,ALT,total protein and albumin in AIDS patients with antiretroviral therapy.However,the efficacy of antiretroviral therapy needs to be evaluated with a long period of scientific observation.