无味氯霉素的合成工艺改进

Optimization on Synthesis of Tasteless Chloramphenicol

目的改进无味氯霉素的合成工艺。方法用三乙胺作催化剂制备活性中间体,在后处理过程中对粗品用正己烷处理。结果将成品(纯度99%以上)总收率提高到86.8%,简化了后处理过程,使得后处理时间缩短,减少了溶剂消耗。结论本实验找到了反应条件稳定,后处理方法简单并可用于大生产的合成路线,大大降低了工业成本,同时产品纯化过程简单易行,易用于工业化生产。

Objective To improve the tasteless chloramphenicol synthesis technology.Methods Use triethylamine as catalyst to prepare activated intermediates,and in the post-processing we used hexane to dispose the crude.Results The finished product（more than 99% purity） total yield was improved to 86.8%,it simplifies the process of post-processing,shortened the processing time,reduced solvent consumption.Conclusions This experiment found a synthetic route that with stable reaction condition and simplicity that is suitable for mass production which significantly reduces industrial costs,and also makes product purification process simple and easily for industrial production.