蒜头果油中长链脂肪酸选择性合成大环内酯

Selective synthesis of macrocyctic lactones via long-chain unsaturated fatty acids of malania oleifera chum oil

研究了蒜头果油脂中长链不饱和脂肪酸的臭氧氧化以及ω-羟基脂肪酸的催化关环合成大环内酯,考察了臭氧氧化切断双键选择性和大环内酯化选择性。结果表明,不饱和脂肪酸的碳链越长,越有利于臭氧氧化反应和生成大环内酯。蒜头果油脂合成大环内酯的产率为:环十五内酯36.9%,环十三内酯为22.4%,环十一内酯1.0%,并探讨了蒜头果油脂中油酸的反应特性。

Using malania oleifera chum oil as raw material,macrocyctic lactones was synthesized by ozonization of long-chain unsaturated fatty acids and cyclization for ω-hydroxycarboxylic acids.Ozonization selectivity of double bonds and cyclization selectivity were investigated.The results showed that it was benefitial for ozonation reaction and formation of macrocyctic lactones with the longer cyclotridecanolide carbon and 11-undecalactone chain in unsaturated fatty acids.The yield of cyclopentadecanolide was 36.9%,22.4%,and 1.0%,respectively.The reaction characteristic of oleic acid in malania oleifera chum oil was discussed.