3,7-二氨基-2,8-二甲基-5-苯基吩嗪盐酸盐合成研究

Study on synthesis of 3,7-diamino-2,8-dimethyl-5-phenylphenium chloride

以邻甲基苯胺、2,5-二氨基甲苯和苯胺为原料,经氧化反应,合成3,7-二氨基-2,8-二甲基-5-苯基吩嗪盐酸盐,讨论了反应条件对反应收率的影响。结果表明,当n（2,5-二氨基甲苯）∶n（2-氨基甲苯）∶n（苯胺）∶（重铬酸钠）=1∶1∶1∶1.945,pH值为6~8,40~45℃反应4 h;98~102℃反应3 h,3,7-二氨基-2,8-二甲基-5-苯基吩嗪盐酸盐的收率为93.6%。

3,7-Diamino-2,8-dimethyl-5-phenylphenium chloride was synthesized using 2-aminotoluene,2,5-diaminotoluene and aniline as raw materials by oxidation-condensation reaction.The effect of reaction conditions on yield was studied.The yield of 3,7-diamino-2,8-dimethyl-5-phenylphenium chloride was 93.6% under optimum conditions.The conditions were as follows：n（2,5-diaminotoluene）∶n（2-aminotoluene）∶n（aniline）∶n（NaCr2O7·2H2O）=1∶1∶1∶1.945,pH=6~8,40~45 ℃ for 4 h,98~102 ℃ for 3 h.