期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

CYP3A基因在肿瘤中的研究进展 被引量：1

下载PDF
导出
摘要 细胞色素氧化酶P450（CYP450）作为重要的药物Ⅰ相代谢酶,广泛参与药物在人体内羟化、氧化、还原、水解等多种Ⅰ相反应。CYP4503A（CYP3A）是CYP450家族中的重要成员,
作者 张发良 闵大六
机构地区 蚌埠医学院第一附属医院肿瘤内科
出处 《蚌埠医学院学报》 CAS 2011年第2期201-204,共4页 Journal of Bengbu Medical College
关键词 肿瘤 CYP3A 基因表达调控 肿瘤 肿瘤/药物疗法 综述
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献26

  • 1Gibson GG,Plant NJ,Swales KE,et al.Receptor-dependent transcriptional activation of cytochrome P4503A genes:induction mechanisms,species differences and interindividual variation in man[J].Xenobiotica,2002,32(3):165-206.
  • 2Lamba JK,Lin YS,Schuetz EG,et al.Genetic contribution to variable human CYP3A-mediated metabolism[J].Adv Drug Deliv Rev,2002,54(10):1274-1294.
  • 3Nicola FS,William DF,Alex S,et al.Recent advances in pharmacogenetic approaches to anticancer drug development[J].Drug Dev Res,2004,62(3):233-253.
  • 4Chen CS,Jounaidi Y,Waxman DJ,et al.Enantioselective metabolism and cytotoxicity of R-IFOSFAMIDE and S-IFOSFAMIDE by tumor cell-expressed cytochromes P450[J].Drug Detab Dispos,2005,33(9):1261-1267.
  • 5Pakakasama S,Mukda E,Sasanakul W,et al.Polymorphisms of drug metabolizing enzymes and risk of childhood acute lymphoblastic leukemia[J].Am J Hematol,2005,79(3):202-205.
  • 6黄珍,柴忆欢,岑建农,何海龙,李捷,卢俊.CYP3A5基因多态性与儿童急性白血病的相关性研究[J].中华儿科杂志,2007,45(7):546-548. 被引量：5
  • 7Felix CA,Walker AH,Lange BJ,et al.Association of CYP3A4 genotype with treatment-related leukemia[J].Proc Natl Acad Sci U S A,1998,95(22):13176-13181.
  • 8Lopes LF,Piccoli Fde S,Paixao VA,et al.Association of CYP3A4 genotype with detection of Vγ/Jβ trans-rearrangements in the peripheral blood leukocytes of pediatric cancer patents undergoing chemotherapy for ALL[J].Leuk Res,2004,28(4):1281-1286.
  • 9Leskela S,Honrado E,Montero-Conde C,et al.Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer[J].Endocr Relat Cancer,2007,14(3):645-654.
  • 10Stone A,Ratnasinghe LD,Emerson GL,et al.CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians[J].Cancer Epidemiol Biomarkers Prev,2005,14(5):1257-1261.

二级参考文献8

  • 1Felix CA, Wakler AH, Langer BJ, et al. Association of CYP3A4 genotype with treatment-related leukemia. Proc Natl Acad SCI USA,1998, 95:13176-13181.
  • 2van Schaik RH, van der Heiden IP, wan den Anker JN,et al. CYP3A5 variant allele frequencies in Dutch Caucasians. Clin C hem, 2002,48 : 1668 -1671.
  • 3Rothman N, Wacholder S, Caporaso NE, et al. The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogens. Biochim Biophys Acta,2001,1471 : C1-C10.
  • 4Jatinder KL,Yvonne SL, Thummel KE, et al. Genetic contribution to variable human CYP3A-mediated metabolism. Advanced drug delivery reviews, 2002,54 : 1271-1294.
  • 5Wojnowski L. Genetics of the variable expression of CYP3A in humans. Ther Drug Monit, 2004,26 : 192-199.
  • 6Kuehl P, Chang J, Lin Y, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet ,2001,27 : 383-391.
  • 7Pakakasama S, Mukda E, Sasanakui W, et al. Polymorphisms of drug metabolizing enzymes and risk of acute lymphoblastic leukemia. Am J Hematol,2005 ,79 :202-205.
  • 8Goh BC, Lee SC, Wang Lz, et al. Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies. J Clin Oncol, 2002,20 : 3683 -3690.

共引文献4

同被引文献13

引证文献1

蚌埠医学院学报
2011年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部