肥胖与非肥胖老年高血压患者血清生长激素水平比较及相关因素分析

Analysis of growth hormone level and related factors in obese and non-obese elderly patients with hypertension

目的比较肥胖与非肥胖老年高血压患者血清生长激素(GH)水平的差异,探讨其与心血管危险因素的相关性。方法根据体质量指数(BMI)及腰围(WC),将80例老年高血压患者分为肥胖组及非肥胖组,测定WC、GH、空腹血糖(FPG)、空腹胰岛素(FINS)、血脂、纤维蛋白原(Fb)、收缩压(SBP)、舒张压(DBP),C反应蛋白(CRP),计算胰岛素抵抗指数(HOMA-IR)。结果 (1)肥胖组GH、高密度脂蛋白胆固醇(HDL-C)低于非肥胖组,两者差异均有统计学意义(P<0.05或P<0.01);(2)肥胖组FPG、FINS、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、Fb、SBP、DBP、CRP、HOMA-IR高于非肥胖组,2组差异均有统计学意义(P<0.05或P<0.01);(3)GH与HDL-C呈正相关,与WC、BMI、HOMA-IR、TG、TC、CRP、Fb及年龄呈负相关。结论肥胖的患者GH水平下降,并与心血管危险因素密切相关,GH水平降低可能预示心血管疾病的高风险。

Objective To compare the difference of growth hormone （GH） between obese and non-obese in elderly patients with hypertension, and to investigate the relativity between GH and the risk of cardiovascular disease. Methods According to different body mass index（BMI） and waist circumferences（WC） ,80 subjects were divided into two groups： obesity group and non-obesity group. WC, GH, fasting plasma glucose （ FPG）, fasting insulin （ FINS）, lipid, fibrin （ Fb）, C reactive protein （CRP） ,systolic blood pressure（SBP） ,diastolic blood pressure（DBP） were measured. HOMA-IR was calculated. Results （ 1 ） GH and HDL-C in patients with obesity decreased remarkably as compared with non-obesity group （ P 〈 0. 05 or P 〈 0. 01 ）. （ 2 ） FPG, FINS,TG, TC, LDL-C, Fb, CRP, SBP, DBP and HOMA-IR were elevated significently in obese patients（ P 〈 0.05 or P 〈 0.01 ）. （3） GH was positively correlated with HDL-C, and negatively correlated with WC, BMI, HOMA-IR,TG,TC,LDL-C,Fb,CRP and age. Conclusions The level of GH significantly decreases in obese patients, and it is highly related to cardiovascular risk. Decreased GH secretion may be associated with increased high risk of cardiovascular disease.