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奥美沙坦酯对心肌梗死小鼠NADPH氧化酶的作用 被引量：1

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摘要 目的探讨奥美沙坦酯(OLM)对心肌梗死(MI)小鼠NADPH氧化酶的作用。方法健康C57小鼠分为假手术组(SHAM组)、MI组和OLM组。建立小鼠MI模型,OLM组以10 mg/kg剂量每日胃饲,4周时观察各组小鼠病死率及一般状况;AZAN染色观察小鼠心脏纤维化情况,TBA法检测心内丙二醛(MDA)含量;Real-time PCR法检测心肌gp91phox、p22phox和p47phox的表达情况。结果 SHAM组和OLM组术后均存活,MI组病死率为20%。与SHAM组比较,MI组心脏AZAN染色阳性区域增大,OLM组较MI组显著降低。与SHAM组比较,MI组心脏MDA水平增高,gp91phox、p22phox和p47phox表达增高(P<0.05),OLM组心脏MDA水平,gp91phox、p22phox和p47phox表达较MI组降低(P<0.05)。结论 MI可激活心内NADPH氧化酶,参与心肌纤维化过程,OLM通过抑制NADPH氧化酶活性起到保护作用。
作者 张恒 刘是中
机构地区 中国医科大学临床医药学院
出处 《山东医药》 CAS 北大核心 2011年第4期44-45,共2页 Shandong Medical Journal
关键词 奥美沙坦酯 心肌梗塞 NADPH氧化酶
分类号 R363 [医药卫生—病理学]
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参考文献7

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引证文献1

山东医药
2011年 第4期

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