抑郁症患者恐惧与中性面孔刺激的脑磁图研究

The neural substrates during processing of fear and neutral faces in major depressive patients:a magnetoencephalography study

目的:利用脑磁图探讨抑郁症患者给予重复恐惧、中性面孔刺激后早期神经磁场激活特征。方法:8例抑郁症患者及12名健康右利手对照者,在给予恐惧、中性面孔图片刺激同时记录脑磁图信号,使用SPM8b软件进行数据分析;设两样t检验P<0.005(未校正)和K值≥40个体素范围为差异有统计学意义。结果:在0～50Hz频率范围内,与对照组相比,抑郁组在恐惧面孔图片刺激下显示出左侧眶额皮质、腹外侧前额皮质激活增强;在中性面孔刺激下,抑郁组显示出左侧腹外侧前额皮质和眶额皮质、左前扣带回激活增强,双侧顶叶如楔前叶等激活减弱。结论:抑郁症患者情绪感受脑区左侧前额皮质低频脑磁图功率增强。

Objective： To explore the neural mechanism of major depressive patients during early stage processing of repeating fear and neutral faces stimuli using magnetoencephalography（MEC）. Method：Eight patients and twelve right-handed healthy individuals were silently viewing fear and neutral faces.Data was collected using MEG and analyzed using SPM8b software.Two sample t-test was used to find the difference of brain activation, voxels with a P value0.005（uncorrected） and cluster size≥40voxels were determined significant difference. Results：Compared to controls in 0~50 Hz,during fear faces presenting,depressive patients showed increased activity in left orbitofrontal cortex（OFC） and ventrolateral prefrontal cortex（VLPFC）;While neutral faces presenting,depressive patients exhibited increased brain activity in left VLPFC and OFC、left anterior cingulate cortex（ACC）,but decreased activity in bilateral parietal lobe such as precuneus. Conclusion：The power of left prefrontal cortex which has function to evaluate emotion increased in major depressive patients detected by low frequency MEG.