γ-氨基丁酸对亚综合征性抑郁认知功能的作用

Effect of sertraline with gamma-aminobutyric acid on cognitive function of the subsyndromal symptomatic depression

目的:探讨舍曲林联合γ-氨基丁酸(GABA)对亚综合征性抑郁(SSD)认知功能的影响。方法:83例SSD患者分为单用药组(单用舍曲林治疗)45例和合用药组(舍曲林联合GABA治疗)38例。疗程12个月。于治疗前和治疗12个月采用抑郁自评量表(SDS)、韦氏成人智力量表(WAIS)、临床记忆量表、威斯康星卡片分类测验(WCST)评定认知功能和抑郁症状严重度。结果:治疗后两组SDS、WAIS、WCST和临床记忆量表的指向记忆、联想学习、记忆商数以及合用药组的图像自由回忆均较治疗前有显著改善(P<0.05或P<0.01);以合用药组的联想学习、记忆商数、WCST正确百分数和随机错误数成绩较单用药组明显为好(P<0.05)。结论:GABA联合舍曲林对亚综合征性抑郁认知功能的改善较单用舍曲林更为显著。

Objective： To investigate the effect of sertraline with gamma-aminobutyric acid on cognitive function of subsyndromal symptomatic depression （SSD）. Method：83 SSD patients were assigned to either group A（n=45） receiving sertraline or group B （n=38） receiving sertraline with GABA therapy for 12 month.Wechsler adult intelligence scale （WAIS）,clinical memory scale （CMS） and Wisconsin cards sorting test （WCST） were used to evaluate cognitive function,and self depression scale （SDS） to evaluate the symptom severity before and after treatment. Results：After treatment,both groups showed significantly improvement in SDS, all subscales of WAIS, WCST,and auditory recall,paired-association and total MQ of CMS （P0.05 or P0.01）;but group B showed more improvement in paired-association as well as total MQ of CMS and correct numbers as well as random errors of WCST （P0.05）. Conclusion：Both sertraline and GABA treatment may be superior to sertraline treatment for improving cognition of SSD.