广泛性焦虑与强迫症患者条件负变化对照研究

A comparative study of contingent negative variation between patients with generalized anxiety disorder and obsessive compulsive disorder

目的:用新的分析软件验证彩照诱发条件负变化(CNV)在广泛性焦虑(GAD)和强迫症(OCD)中的临床价值。方法:应用美国NicoletBravo脑诱发电位仪,采用彩照诱发以及反应时间技术,记录了41例GAD和69例OCD患者的CNV,并与58名正常对照者(NC)CNV进行比较。结果:①OCD组波形不规则,CNV-Ⅱ型尤甚;②OCD组、GAD组及NC组在命令信号后负变化(PINV),波幅M1上差异有显著性(P<0.01);与NC组相比,GAD组波幅M1降低,OCD组波幅M1增高;③与NC组相比,OCD和GAD组PINV出现率明显增多,OCD组最高,GAD组其次。结论:新软件为CNV临床应用提供强有力的技术支持。CNV可能是评定GAD和OCD大脑综合功能的有效工具之一,OCD患者CNV变化诸特点值得跟踪随访。

Objective： To assess the clinical value of contingent negative variation （CNV） in diagnosing generalized anxiety disorder （GAD） and obsessive compulsive disorder （OCD） by a new analytic software. Method：Event-related potentials CNV of 41 GAD,69 OCD patients and 58 normal controls were recorded using a Nicolet Bravo Instrument and compared among them. Results：①OCD patients presented irregular CNV wave,especially in CNV-Ⅱ type.②A significant difference of CNV was found among 3 groups,in both PINV and amplitudes of M1 （P0.01）;compared with NC,GAD patients showed decreased M1 amplitude,and OCD patients showed increased M1 amplitude.③Compared with NC,two patient groups had increased ratio of PINV appearance,mostly in OCD patients,secondly in GAD patients. Conclusion：The new analytic software can provide strongly technique support for application of CNV to clinical diagnosis.CNV may be a useful instrument for assessing the brain function of GAD and OCD.The characteristics of CNV in OCD patients deserve further studying.