奥氮平对伴有焦虑的抑郁症的治疗作用

An effect of olanzapine in treatment of depression with anxiety symptoms

目的:观察西酞普兰合并小剂量奥氮平治疗伴有焦虑的抑郁症患者的临床疗效和安全性。方法:将68例伴有焦虑的抑郁症患者随机分为两组,研究组给予西酞普兰合并奥氮平治疗,对照组给予西酞普兰治疗,疗程均为8周。采用汉密尔顿抑郁量表(HAMD)及汉密尔顿焦虑量表(HAMA)评定临床疗效,治疗中出现的症状量表(TESS)评定不良反应。结果:治疗8周末两组HAMD及HAMA评分均显著性下降(P均<0.01)。研究组起效较快,显效率高于对照组(P<0.05),两组不良反应均较轻微。结论:西酞普兰合并奥氮平对伴有焦虑的抑郁症起效快,疗效肯定,安全性高,依从性好。

Objective：To assess the clinical efficacy and safety of citalopram combined with low dose olanzapine in treatment of depression with anxiety symptoms. Method：68 depressive patients with anxiety symptoms were randomly divided into research group which received citalopram plus olanzapine treatment and control group which received citalopram treatment for 8 weeks.Curative effects were assessed using Hamilton depression scale （HAMD） and Hamilton anxiety scale （HAMA）.Adverse reactions were assessed with treatment emergent symptoms scale （TESS）. Results：The two groups showed significant score decreases on HAMD and HAMA,but the research group showed faster score drop on HAMD and HAMA and had higher effective rate than control group.There were no significant differences on TESS score between the two groups. Conclusion：Citalopram plus olanzapine is effective and safe and has better compliance in treatment of depression with anxiety symptoms.