阿立哌唑合并锂盐治疗躁狂症临床观察

The curative effect of aripiprazole combined with lithium on mania

目的:探讨阿立哌唑合并锂盐治疗躁狂症的临床疗效。方法:将83例躁狂症患者随机分成阿立哌唑合并锂盐组(研究组)和锂盐组(对照组)治疗6周。于治疗前和治疗后第4天和第1、2、3、6周用Bech-Rafaelsen躁狂量表(BRMS)、临床疗效总评量表(CGI-SI)和治疗中出现的症状量表(TESS)评定病情的严重程度、疗效和不良反应。结果:研究组和对照组在治疗后第4天、1周、2周、3周后BRMS评分差异有显著性(P<0.05),研究组降分较快,不良反应相仿。结论:阿立哌唑合并锂盐治疗躁狂症出现疗效较单用锂盐快。

Objective：To study the curative effect of aripiprazole combined with lithium in treatment of mania. Method：83 manic patients were assigned into either study group which received aripiprazole plus lithium treatment or control group which received lithium treatment for six weeks.Bech-Rafaelsen mania rating scale （BRMS）,clinical global impression （CGI-SI） and treatment emergent symptom scale （TESS） were conducted at baseline,day 4,week 1,2,3 and 6. Results：The study group showed more score decrease on BRMS and CGI-SI at day 4,week 1,2 and 3 （P0.05）,which indicated aripiprazole combined with lithium worked faster.There were no significant side effect differences between the two groups. Conclusion： Aripiprazole combined with lithium can have earlier curative effect in treatment of mania than lithium.