急性热应激小鼠血浆心钠素、血管紧张素及其体液Na^+/K^+的变化

EFFECT OF ACUTE HEAT STRESS ON THE LEVEL OF ATRIAL NATRIURETIC PEPTIDE,ANGIOTENSIN AND HUMORAL Na +/K + IN MICE

观察了小鼠在热应激以及热应激恢复期血浆心钠素（ＡＮＰ）、血管紧张素（ＡⅡ）及其体液中Ｎａ＋／Ｋ＋的变化。结果表明：经热应激后小鼠血浆ＡＮＰ含量无明显变化，ＡⅡ含量则明显上升，Ｎａ＋／Ｋ＋明显减少，肺指数也明显升高；而在热应激的恢复期，小鼠血浆ＡＮＰ却极显著上升，为对照组的２５０％，而ＡⅡ却极显著下降，为对照组的４７％，尿Ｎａ＋／Ｋ＋值仍持续降低，而肺指数却回降到正常水平。这些结果揭示：ＡＮＰ、ＡⅡ共同参与了热应激的过程，共同调节机体的水、盐代谢，维持机体的稳态。

In this paper,the effect of acute heat stress on th e level of natriuretic peptide (ANP),angiotensin (AⅡ) and humoral Na +/K + i n mice was investigated.The results showed that there was no significant change of the ANP level in plasma with treatment of heat stress.On the contrary the lev el of plasma AⅡ and lung index markedly increased,and the Na +/K + decreased .In recovery stage,the ANP level rapidly increased to 250% of the control,at the same AⅡ content in plasma decreased to 47% of the control,Na +/K + conti nuously decreased,the lung index decreased to normal level. These results indicated that ANP and AⅡ were involved in the progress of heat s tress and play a key role in regulating metabolism of water and salt,by which b ody damage is protected and homeostasis were thus maintained.