1Demeo DL,Silverman EK.α1-Antitrypsin deficiency:genetic aspects of a1-antitrypsin deficiency:phenotypes and genetic modifiers of emphysema risk[J].Thorax,2004,59(3):259-64.
3Stockley RA,Luisetti M,Miravitlles M,et al.Ongoing research in Europe:Alpha One International Registry(AIR) objectives and development[J].Eur Respir J,2007,29(3):582-6.
4Zorzetto M,Russi E,Senn O,et al.SERPINA1 Gene Variants in Individuals from the General Population with Reduced α1-Antitrypsin Concentrations[J].Clinical Chemistry,2008,54(8):1331-8.
6Higashimoto YJ,Yamagata YK,Taya S,et al.Systemic inflammation in chronic obstructive pulmonary disease and asthma:Similarities and differences[J].Respirology,2008,13(1):128-33.
7Dawkins PA,Dawkins CL,Wood AM,et al.Rate of progression of lung function impairment in a1-antitrypsin deficiency[J].Eur Respir J,2009,33(6):1338-44.
8Campos MA,Alazemi S,Zhang G,et al.Clinical Characteristics of Subjects With Symptoms of α1-Antitrypsin Deficiency Older Than 60 Years[J].Chest,2009,135(3):600-8.
9Bernspang E,Sveger T,Piitulainen E.Respiratory symptoms and lu-ng function in 30-year-old individuals with alpha-1-antitrypsin deficiency[J].Respir Med,2007,101(9):1971-6.
4Birke FW, Meade CJ, Anderskewitz R, et al, In vitro and in vivo pharmacological characterization of BIIL284, a novel and potent leukotriene B4 receptor antagonist[J]. J Pharmacol Exp Ther, 2001,297:458 - 466.
5Shindo K, Hirai Y, Fukumura M, et al. Plasma levels of leukotriene E4 during clinical course of chronlc obstructive pulmonary dlsease[J]. Prostaglandins Leukot Essent Fatty Acids, 1997,56:213-217.
6Crooks SW, Bayley DL, Hill SI, et al. Bronchial in flammation inacute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4[J]. Eur Respir J, 2000,15:274 - 280.
7Stoller J K,Aboussouan L S.Alpha1-antitrypsin deficiency[J].Lancet,2005,365:2225-2236.
8Frederick J.World wide racial and ethnic distribution of AAT deficiency surveys[J].Chest,2002,122:1818-1829.
9Crowther DC, Belorgey D, Miranda E, et al. Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies. Eur J Hum Genet, 2004,12: 167-172.
10Hersh CP, Dahl M, Ly NP, et al. Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis. Thorax, 2004, 59: 843-849.
