子宫内膜异位症患者高迁移率蛋白-1与高敏C反应蛋白的含量变化

Increased levels of prostaglandin high mobility group box-1 and high-sensitive C-reactive protein in peritoneal fluid and serum of patients with endometriosis

检测76例子宫内膜异位症（EMS）患者（EMS组）（Ⅰ、Ⅱ期36例,Ⅲ、Ⅳ期40例）和30例因卵巢囊肿或浆膜下子宫肌瘤手术患者（对照组）腹腔液及血清高迁移率蛋白-1（HMGB1）、高敏C反应蛋白（Hs-CRP）含量.EMS组患者腹腔液中HMGB1、Hs-CRP的含量明显高于对照组,（8.2±0.8）mg/L比（2.1±0.2）mg/L、（14.4±3.0）mg/L比（4.5±2.3）mg/L（均P＜0.01）.Ⅲ、Ⅳ期EMS患者腹腔液中HMGB1、Hs-CRP的含量较Ⅰ、Ⅱ期患者升高,（9.2±0.8）mg/L比（6.7±0.7）mg/L、（18.7±2.9）mg/L比（11.2±2.8）mg/L,差异有统计学意义（均P＜0. 05）,同时Ⅲ、Ⅳ期EMS患者血清中HMGB1、Hs-CRP的含量也高于Ⅰ、Ⅱ期患者,（6.5±0.6）mg/L比（3.4±0.5）mg/L、（8.4±2.7）mg/L比（5.4±2.4）mg/L.同时EMS组患者HMGB1与Hs-CRP的含量之间存在正相关（r=0.72,P＜0.01）.EMS患者高含量的HMGB1与Hs-CRP可作为判断EMS病情的参考指标.

The concentrations of prostaglandin in high mobility group box-1 （ HMGB1 ） and highsensitive C-reactive protein （Hs-CRP） in serum and peritoneal fluid were detected in 76 patients with endometriosis （study group） and 30 patients without endometriosis （ovary cysts or uterine myoma, as control group）. The peritoneal fluids were collected during laparoscopic operation, and the serum samples were collected before surgery. The HMGB1 and Hs-CRP concentrations in serum and peritoneal fluid of study group were significantly higher than those of control group, （ 8. 2 ± 0. 8） mg/L vs. （2. 1 ±. 0. 2） mg/L、 （ 14. 4 ±3.0） mg/L vs. （4.5 ±2.3） mg/L （both P〈0. 01）;HMGB1 and Hs-CRP levels in serum and peritoneal fluid of stage Ⅲ-Ⅳ endometriosis were significantly higher than those of stage Ⅰ-Ⅱ, （ 9. 2 ± 0. 8） mg/L vs.（6.7 ±0.7） mg/L,（18.7 ±2.9） mg/L vs. （11.2 ±2. 8） mg/L,（6.5 ±0.6） mg/L vs. （3.4 ±0.5） mg/L,（8.4 ±2.7） mg/L vs. （5.4 ±2.4） mg/L （all P 〈0.05）. The concentrations of HMGB1 were positively correlated with Hs-CRP in endometriosis group （r =0. 72, P 〈0. 01 ）. The results indicate that concentrations of HMGB1 and Hs-CRP may be of value in assessing the severity of endometrosis.