首发精神分裂症患者细胞因子水平对照研究

The cytokine level of first-episode schizophrenia patient

目的探讨首发精神分裂症患者的细胞因子水平，为揭示精神分裂症的病因、发病机制、临床诊断及治疗提供理论依据。方法将78例首发精神分裂症患者设为研究组，35名正常健康体检者设为对照组，采用放射免疫分析法检测两组血浆白细胞介素-18、白细胞介素-2、白细胞介素-6、白细胞介素-8、肿瘤坏死因子-a，研究组于治疗1周、8周末采用阳性与阴性症状量表评定精神症状。结果研究组血浆白细胞介素-1B、白细胞介素-2、白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α水平均显著高于对照组（P〈0．05或0．01）。研究组血浆肿瘤坏死因子-a升高与白细胞介素-lp水平升高呈显著正相关，阳性与阴性症状量表评分与白细胞介素水平无显著相关性。Ⅰ型精神分裂症患者白细胞介素-2水平显著高于Ⅱ型患者（P〈0．01），白细胞介素-8水平显著低于Ⅱ型患者（P〈0．05）。结论精神分裂症患者的免疫功能处于亢进状态，细胞因子水平与精神病理存在-定相关性。

Objective To explore the cytokine level of first-episode schizophrenia patient in order to provide theory basis for revealing cause of disease, pathogenesis, clinical diagnosis and treatment. Methods Seventy-eight first-episode schizophrenis were assigned to research group and 35 normal examinees to control group. Plasma IL-1β, IL-2, IL-6, IL-8, and TNF-α were detected using radio immunoassay and mental symptoms were assessed with the Positive and Negative Syndrome Scale （PANSS） at the end of the 1st and 8th week in the research group. Results Plasma levels of plasma IL-1β, IL-2, IL-6, IL-8 and TNF-α were significantly higher in the research than in the control group （P〈0. 05 or 0. 01）. In the research group, plasma TNE-α elevation ws significantly positively related to IL-1β elevation, there were no notable correlation between the PANSS score and IL levels. IL-2 levels were significantly higher （P^0. 01） and IL-8 lower（P〈0.05） in type Ⅰ than in type Ⅱ schizophrenics. Conclusion The immune function of schizophrenia patient is in hyperfunction, cytokine level has a certain correlation to psychopathology.