药物联合康复训练治疗老年痴呆对照研究

Drugs combined with rehabilitation training in senile dementia

目的评价药物联合康复训练治疗老年痴呆的临床效果。方法将70例老年痴呆患者随机分为两组，每组35例。两组均接受常规药物治疗、基础护理、健康教育及肢体功能康复指导。观察组在此基础上联合康复训练。观察12周。于康复训练前及训练12周末，采用简易智力状态检查量表、护士用住院病人观察量表、日常生活自理能力量表评定临床效果。结果康复训练12周末，两组简易智力状态检查量表、护士用住院病人观察量表评分均较训练前显著升高（P〈0．05或0．01）；观察组日常生活自理能力量表评分较训练前有所降低，对照组有所升高，但差异均无显著性（P〉0．05）。康复训练前两组各量表评分差异均无显著性（P〉0．05）；训练后观察组简易智力状态检查量表、护士用住院病人观察量表评分显著高于对照组（P〈0．05或0．01），日常生活自理能力量表评分显著低于对照组（P〈0．05）。结论药物联合康复训练能延缓老年痴呆患者的病情发展、改善认知功能、提高生活自理能力，显著优于单用药物治疗。

Objective To evaluate the clinical efficacy of drugs combined with rehabilitation training in senile dementia. Methods Seventy senile dementia patients were randomly assigned to two groups of 35 ones eeach. Both groups received routine pharmacotherapy, basic nursing, health education and limbs functional rehabilitation guidance, and observation group was plus rehabilitation training for 12 weeks. Clinical effieacies were assessed with the Mini-ental State Examination （MMSE）, the Nurses Observation Scale for Inpatient Evaluation （NOSIE） and the Activity of Daily Living Scale （ADL） before rehabilitation training and the end of the 12th week. Results At the end of the 12^th week, the MMSE and NOSIE score of both groups heightened more significantly compared with pre-training （P〈0.05 or 0.01） ; the ADL score lowered to some extent in the observation and heightened in the control group compared with pre-raining, but the differences were not significant （P〉 0. 05）. Before training, there were no significant differences in the scores of all scales between the two groups （P〉0.05）; after training, the MMSE and NOSIE score were significantly higher （P〈0.05 or 0.01） and the ADL lower （P〈0.05） in the observation than in the control group. Conclusion Drugs combined with rehabilitation training could postpone the progression of disease, improve cognitive function, increaese self-care ability, and have an advantage over pharmacotherapy only in senile dementia.