弥漫性肺间质疾病中医基础证候的文献研究

Literature study on Chinese medicine basic syndromes of diffuse interstitial lung disease

目的:基于文献分析弥漫性肺间质疾病中医基础证候分布规律及特征。方法:从中国生物医学文献数据库、中国学术期刊全文数据库和中国中医药文献检索系统数据库,检索近15年相关文献,筛选整理规范名称,建立数据库,采用统计描述和Logistic回归进行分析。结果:咳嗽、喘促、气短、进行性呼吸困难、紫绀和痰少是弥漫性肺间质疾病最常见的临床表现,血瘀证、痰湿证、痰热证、肺气虚证、肺阴虚证、肾气虚证、肾阴虚证和肾阳虚证是其基础证候,单一的基础证候少见,肺间质纤维化多以复合证候存在。结论:弥漫性肺间质疾病中医基础证候有8个,证候属性有一定规律性,其结果有待进一步临床验证。

Objective： To analysis distribution regularity and characteristic of Chinese medicine basic syndromes of diffuse interstitial lung disease（DILD） based on literature.Methods： Literatures were collected from CBM,CNKI and TCM database in the late 15 years.The name of the disease was filtered standardized,a database was established.Methods of statistical description and Logistic regression were used to analyze data collected.Results： The cough,respiratory distress,short breath,progressive dyspnea,cyanosis and sputum volume reduced were the most common clinical manifestation of DILD.The blood stasis syndrome,phlegm-damp syndrome,phlegm-heat syndrome,the syndromes of lung qi deficiency,the syndromes of lung yin deficiency,the syndromes of kidney qi deficiency,the syndromes of kidney yin deficiency,the syndromes of kidney yang deficiency were basic syndromes of DILD.The single basic symptom was rare.The complex syndrome was the main manifestation of DILD.Conclusion： There were 8 Chinese medicine basic syndromes of DILD.The syndrome property had some regularity.The research results require further clinical study to be verified.