痛经宁颗粒对原发性痛经患者血清肥大细胞脱颗粒及血清皮质醇含量的影响

Effects of Tongjingning Particles on primary dysmenorrhea patients about mast cell degranulation and cortisol in serum

目的:探讨中药痛经宁颗粒对原发性痛经(PD)患者焦虑症(HAMA)分值、抑郁症(HAMD)分值与血清肥大细胞(MC)脱颗粒类胰蛋白酶(MCT)及血清皮质醇(CS)含量的相关影响。方法:收集72例原发性痛经患者,随机分为中药组、西药组,均治疗1个疗程,并以18例正常者为对照。观察治疗前、后各组患者血清HAMA、HAMD分值与MCT、CS含量的变化。结果:原发性痛经患者HAMA、HAMD分值及血清MCT、CS含量显著高于正常组(P<0.05)。治疗后,中药组HAMA、HAMD积分值、血清MCT、CS含量显著降低,并低于西药组治疗后(P<0.05),西药组有下降趋势,但并无统计学意义。结论:PD患者存在焦虑、紧张、抑郁状态且与血清MC高表达、CS高水平呈正相关趋势。中药痛经宁颗粒调节精神情绪、降低血清中CS含量,减轻MC细胞脱颗粒,缓节应激等作用显著优于西药阿司匹林。

Objective： To observe the effects of Tongjingning Particles on primary dysmenorrhea patients about mast cell degranulation,cortisol in serum,as well as the effect in reducing the score ahout HAMA and HAMD.Methods： A 72 Clinical collection was divided into traditional Chinese medicine treatment of dysmenorrhea Granule group,western medicine aspirin treatment group randomly.At the same time 18 mormal person play the role of control group.Measured MC degranulation in peripheral blood of a product of tryptase and cortisol content,as well as the scroe of HAMA and HAMD.Comparative analysis of patients in each group content of the above-mentioned changes in indicators.Results： HAMA and HAMD scores of PD patients were significantly higher than the normal group before treatment（P0.05）.After treatment HAMA and HAMD scores of Chinese medicines group,as well as MCT and CS content were significantly lower than before treatment（P0.01）.Compared with the normal group,there is no significant difference.Western medicine group points are on a downward trend after treatment.However,compared with pre-treatment there is no significant difference.Conclusion： The patients of PD have the anxiety and depression.And this is related with the higher level of MCT and CS in serum.Tongjingning can significantly improve the anxiety,depression and inhibit the extent of MC degranulation in patients of PD.