p53,VEGF,Bcl-2在进展期胃癌组织中的表达

Expression of P53,VEGF and Bcl-2 in advanced gastric carcinoma

目的:探讨p53、VEGF、bcl-2基因在进展期胃癌中的表达与胃癌发生的关系。方法:采用免疫组化技术检测p53、VEGF、bcl-2基因在37例进展期胃癌、40例良性病变(慢性浅表性胃炎、息肉、非典型增生)胃黏膜组织中的表达。结果:p53,VEGF,bcl-2基因表达阳性率在胃癌组织中均明显高于正常组织(P<0.05)。结论:p53,VEGF,bcl-2在胃癌的发生发展中起着独立而又协调的作用。

Objective：To study expression of p53,VEGF and bcl-2 in advanced gastric carcinoma and its relation with occurrence of gastric cancer.Methods：To adopt immunohistochemical technology to measure p53,VEGF and bcl-2 genes in 37 cases of advanced gastric carcinoma and 40 cases of benign diseases（chronic superficial gastritis,polypus,atypical hyperplasia）.Results：The positive rates of P53,VEGF and bcl-2 in gastric carcinoma were 61.16%,67.57% and 40.54%,which were higher than those in normal tissues（P0.05）.Conclusion：P53,VEGF and bcl-2 genes have independent and coordinating role in the occurrence and development of gastric carcinoma.