氟西汀与氯丙咪嗪治疗强迫症的对照研究

studies of fluoxetine and clomipramine in the treatment of patients with obsessive-compulsive disorder

目的评价氟西汀与氯丙咪嗪治疗强迫症的疗效和安全性。方法对符合CCMD-3强迫症诊断标准、分别接受父西汀和氯丙咪嗪治疗的共50例强迫症患者进行为期8周的观察,并应用Yale-Brown强迫量表(Y-BOCS)、Marks恐怖强迫量表(MSCPOR)、HAMD、HAMA和TESS量表评估和比较这两种药物治疗强迫症的疗效和不良反应。结果经过8周治疗,氟西汀组与氯丙咪嗪组疗效相近(P>0.05),氟西汀组与氯丙咪嗪组的显效率(痊愈+显著进步)差异无统计学意义(x^2=0.089,P>0.05)。氟西汀组不良反应发生率明显少于氯丙咪嗪组。结论氟西汀与氯丙咪嗪对强迫症均有较好的疗效,但氟西汀具有给药方便、不良反应轻等优点。

objective To evalute the therapeutic effect and safety of fluoxetine and clomipramine in treatment of obsessive-compulsive disorder.Methods Fifty patients according to CCMD-3 criteria were enrolled in this study.Twenty-five patients taking fluoxetine and another twenty-five patients having domipramine for eight weeks.Symptom improvement and side effects were monitored with clinical evaluation,Yale-Browm OCD rating scale,MSCDPOR, HAMD,HAMA and TESS.Results At the end of eight weeks of treatment,there was no significant difference in the efficacy between fluoxetine and clomipramine.However the side effects of fluoxetine were lighter than clomipramine.Conclusion The results indicate that both fluoxetine and clomipramine is effective in the treatment of OCD,but fluoxetine showed more advantages for its convenient administration and the side effects of it were light.