养血生发胶囊的现代药理与毒理学研究进展

Modern Pharmacology and Toxicology Research Progress of Yangxue Shengfa Capsules

目的通过对养血生发胶囊药理和毒理研究进展进行综述,为临床安全、有效、合理地使用该中成药提供资料。方法对国内近二十几年来相关文献进行整理、分析与归纳。从养血、生发、止痒、抗过敏等方面对养血生发胶囊进行了药理研究综述;从急性毒性、肝毒性、对生殖系统的影响等方面进行了毒理研究综述。结果养血生发胶囊具有养血、生发、止痒、抗过敏等药理作用,临床疗效好。但长期服用可引起肝脏损害、肝炎等毒副作用。目前对于整方毒性研究较少;对于处方中各位药材有毒性研究,特别是何首乌肝毒性研究居多。结论养血生发胶囊临床疗效显著,但长期服用可引起肝脏损害、肝炎等毒副作用。针对疗效的系统药效学评价和针对药品不良反应(ADR)报道的毒理学研究以及药效、毒理学机制和相关物质基础研究均需要深入研究。

Objective Pharmacological and toxicological studies on Yangxue Shengfa Capsules are reviewed,in order to provide information for safe,effective and rational use of the medicine clinically.Method Collect,analyze and summarize domestic related literature in recent twenty years.From nourishing blood,hair growth,itching,allergy and other aspects,pharmacological studies on Yangxue Shengfa Capsules are reviewed;germinal capsule review;From acute toxicity,liver toxicity,effects on the reproductive system and other aspects,the toxicological studies on Yangxue Shengfa Capsules are reviewed.Results Yangxue Shengfa Capsules has the pharmacological effects of nourishing blood,hair growth,itching,allergy and so on,and has curative effect in clinical.But the long-term use can cause liver damage,hepatitis and other side effects.At present less toxic studies on the whole prescription,but only for every medicines in the prescription,especially the liver toxicity of Radix Polygoni Multiflori.Conclusion Yangxue Shengfa Capsules has significant clinical effect,but its long-term use can cause liver damage,hepatitis and other side effects.Systematical pharmacodynamics evaluation on the therapeutic effect,research on the toxicology of adverse drug reaction（ADR） report of Yangxue Shengfa Capsules,pharmacological and toxicological mechanisms and its related material basis still need to be researched deeply.