357例抗感染药物不良反应/事件报告分析

Analysis of 357 Cases of Adverse Drug Reaction/Event Reports of Anti-infective Agents

目的了解和分析抗感染药物发生不良反应/事件的情况,为促进临床合理应用抗感染药物提供参考。方法收集2004年1月至2009年11月我院在应用抗感染药物所产生的不良反应报告,从患者情况、不良反应临床表现、给药途径、抗感染药物种类、抗感染的类型及因果关系评价等方面进行分析总结。结果 357例抗感染药物不良反应中,以喹诺酮类药物不良反应例数最多(114例,占31.93%);其次为头孢菌素类(67例,占18.77%)。不良反应累及的系统-器官主要是皮肤及其附件(162例,占45.38%),其次是消化系统(93例,占26.05%)。抗感染药用于抗感染以呼吸系统发生不良反应例数最多(152例,占42.58%),其次是术后抗感染(79例,占22.13%)。结论不合理使用抗感染药是药品不良反应/事件产生的主要因素之一,医疗机构应重视抗感染药物的不良反应,加强抗感染药物临床应用的监管。

Objective To review and analyze the various adverse reaction of anti-infective agents bacterials in order to provide the basis for clinical rational drug use.Methods Data of report adverse drug reaction of anti-infective agents from January 2004 to November 2009 in our hospital were collected.The condition of patients,clinical manifestations of adverse reaction,route of administration,types of antibacterials,types of anti-infection and causality assessment were analyzed.Results 357 cases of adverse reaction of anti-infective agents were involved in the study.The most adverse reaction were caused by quinolones（114 cases,31.93%）,and the cephalosporins followed（67 cases,18.77%）.The most two vulnerable system/organ were skin and its appendages（162 cases,45.38%）,and digestive system（93 cases,26.05%）.Antibiotics for respiratory anti-infective use cause the largest number of cases of adverse reaction（152 cases,42.58%）,followed by anti-infection after surgery（79 cases,22.13%）.Conclusion Irrational use of anti-infective agents was the main reason for the adverse drug reaction/event.Medical institutions should pay more attention to the adverse reactions of anti-infective agents,and strengthen supervision of clinical use of anti-infective agents.