祛浊化痰中药对AS家兔血管成形术后炎性因子表达的影响

Turbid Phlegm Removing Rabbits by High Fat Diet-related Factors After Angioplasty of Inflammatory

目的:观察祛浊化痰中药(通脉颗粒)对高脂饮食兔血管成形术后炎性因子hs-CRP、ICAM-1、NF-KB的影响。方法:选择新西兰大耳白兔50只随机分为空白组、模型组、中药组、西药组、中西药组各10只,通过喂养高脂饲料建立家兔AS模型,8周后造血管内皮球囊拉伤模型,测定hs-CRP含量及各组ICAM-1、NF-KBmRNA表达。结果:通脉颗粒可显著下调高脂饮食兔血管成形术后病灶中hs-CRP含量,且能明显降低家兔血清ICAM-1、NF-KBmRNA表达水平(P<0.05)。结论:通脉颗粒能减少AS斑块内的炎性因子表达,并可抑制血管内皮拉伤后相关炎性因子的表达,以减少AS的形成及防止术后再狭窄。其作用机制可能与调脂、抗炎的作用有关。

Objective： To observe the cured turbid phlegm medicine （Tongmai particles） on the high fat diet rabbits after balloon angioplasty inflammation - associated factor hs - CRP, ICAM - 1, NF - kB effects. Methods： 50 New Zeal- and white rabbits were randomly divided into blank group, model group, group, western medicine group, in the western group 10, through the high fat diet rabbits AS model, to the high fat diet for 8 weeks create vascular endothelial balloon injury model, determination of hs -CRP levels and the group of ICAM -1, NF -KBmRNA expression. Results： Tongmai particles can significantly lower high - fat diet after angioplasty lesions in rabbits hs - CRP levels, and can significantly reduce the rabbit serum ICAM - 1, NF - KBmRNA expression level （ P 〈 O. 05）. Conclusion： AS Tongmai particles can reduce the expression of inflammatory factors within the plaque, and inhibit vascular Neipi La injury related to the expression of inflammatory factors in order to reduce the formation of AS and prevent restenosis. The mechanism may be re- lated to lipid lowering, anti - inflammatory effects.