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Galectin-3的研究现状 被引量:3

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摘要 恶性肿瘤是危害人类生命健康的罪魁祸首,对于如何治疗肿瘤,人们在找寻可能的突破点。凝集素(lectin)被广泛发现于植物及动物组织中,其特异结合糖类的特性,使得不同的凝集素可识别特定的糖结合物提示凝集素可能通过参与或交联特异的糖结合物,在调节生理过程中扮演很重要的角色。Galectins作为一类能结合含半乳糖成分的糖结合物的可溶性凝集素已引起广泛关注。
出处 《山西医药杂志(上半月)》 CAS 2011年第2期143-146,共4页 Shanxi Medical Journal
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参考文献38

  • 1Barondes SH,Castronovo V.Coope DN,et al.Galectins:a family of animal beta-galactoside-binding lectins.Cell,1994,76(4):597-598.
  • 2Liu FT,Rabinovich GA.Galectins as modulators of tumour progression.Nat Rev Cancer,2005,5(1):29-41.
  • 3Hirabayashi J.Arata Y.Kasai K.Galectins from the nematode caenorhabd it is elegans and the genome project.Trends Glycosic Glycotechnol,1997,9(45)i 113-122.
  • 4Barondes SH,Cooper DN.Gitt MA,et al.Galectins structure and function of a large family of animal lectins.J Biol Chem,1994,269(33):20807-20810.
  • 5Gong HCHonjo Y.Nangia-Makker P,et al.The NH2 terminus of Galectin-3 governs cellular compartmen-talization and functions in cancer cells.Cancer Res,1999,59 (24):6239-6245.
  • 6Herrmann J.Turck CW.Atchison RE,et al.Promary structure of the soluble lactose binding lection L-29 from rat and dog and interaction of its non-collagenous praline-,glycine-,tyrosine-rich sequence with bacterial and tissue collagenase.J Biol Chem,1993,268(35):26704-26711.
  • 7Nagy N.Legendre H.Engels O,et al.Refined prognostic evaluation in colon carcinoma a using immunohistochemical galectin fingerprinting.Canter,2003,97(8):1849-1858.
  • 8Liu FT,Hsu DK.Zuberi RI,et al.Expression and function of Galectin-3,a beta-galactoside-binding lectin.in human monocytes and macrophages.Am J Pathol,1995,147 (4):1016-1028.
  • 9Honjo Y,Nangia-Makker P,Inohara H,et al.Down-regultion of Galectin-3 suppresses tumorigenicity of human breas carcinoma cells.Clin Cancer Res,2001,7(3):661-668.
  • 10Hoyer KK,Pang M,Gui D,et al.An anti-apoptotic role for Galectin-3 in diffuse large B-cell lymphomas.Am J Pathol,2004,164(3):893-902.

二级参考文献66

  • 1王丽华,赵咏桔,王晓颖,郑林,肖家诚,徐锦屏,罗邦尧.Galectin-3蛋白在甲状腺肿瘤中的表达及其意义[J].中华内分泌代谢杂志,2004,20(4):300-302. 被引量:6
  • 2邢变枝,毛善平.Galectin-3在人脑星形胶质瘤细胞中的表达[J].卒中与神经疾病,2004,11(6):381-384. 被引量:10
  • 3陈迪文,程春生,于皆平.Galectin-3在胃癌及其转移淋巴结中表达及临床意义[J].广东医学,2005,26(1):51-53. 被引量:7
  • 4[1]Hirabayashi J,Arata Y,Kasai K.Galectins from the nematode Caenorhabditis elegans and the genome project.Trends Glycosic Glycotechnol,1997,9(45):113-122.
  • 5[2]Barondes SH,Cooper DN,Gitt MA,et al.Galectins.Structure and function of a large family of animal lectins.J Biol Chem,1994,269(33):20807-20810.
  • 6[3]Gong HC,Honjo Y,Nangia-Makker P,et al.The NH2 terminus of galectin-3 governs cellular compartmentalization and functions in cancer cells.Cancer Res,1999,59(24):6239-6245.
  • 7[4]Herrmann J,Turck CW,Atchison RE,et al.Primary structure of the soluble lactose binding lectin L-29 from rat and dog and interaction of its non-collagenous proline-,glycine-,tyrosine-rich sequence with bacterial and tissue collagenase.J Biol Chem,1993,268(35):26704-26711.
  • 8[5]Liu FT,Hsu DK,Zuberi RI,et al.Expression and function of galectin-3,a betagalactoside-binding lectin,in human monocytes and macrophages.Am J Pathol,1995,147(4):1016-1028.
  • 9[6]Lotan R,Ito H,Yasui W,et al.Expression of a 31-kDa lactoside-binding lectin in normal human gastric mucosa and in primary and metastatic gastric carcinomas.Int J Cancer,1994,56(4):474-480.
  • 10[7]Nagy N,Legendre H,Engels O,et al.Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting.Cancer,2003,97 (8):1849-1858.

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