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乳腺癌干细胞的研究进展 被引量：2

Research Progress in Breast Cancer Stem Cells
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摘要 乳腺癌干细胞(BCSCs)在乳腺癌的发生、发展、治疗抵抗性、转移及复发中起到了关键作用,为此就乳腺癌干细胞的起源,分选鉴定方法和信号通路、微环境等对BCSCs的的调控关系及其在乳腺癌治疗中的意义进行综述。 Breast cancer stem cells may be the key to coming on,development,resistance in therapy,metaptosis and recrudescence of breast cancer.This paper reviews the origin,the methods of sorting and identification,regulatory pathway,microenviroment and the new potential therapeutic targets elucidated by considering breast cancer as a problem in stem cell biology.
作者 付钰洁 常徽 糜漫天
机构地区 第三军医大学军事预防医学院营养与食品卫生学教研室重庆市营养与食品安全重点实验室 重庆理工大学药学与生物工程学院
出处 《重庆理工大学学报（自然科学）》 CAS 2011年第1期23-28,共6页 Journal of Chongqing University of Technology：Natural Science
基金 国家重点基础研究发展计划(973计划)资助项目(2010CB529403)
关键词 肿瘤干细胞 乳腺癌 细胞分选 信号通路 cancer stem cells breast cancer cell sorting signaling pathway
分类号 R737.9 [医药卫生—肿瘤]
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参考文献36

  • 1AL-HAJJ M,WICHA M S, BEN ITO-HERNANDEZA, et al. Prospective identification of tumorigenic breast cancer cells [ J ]. ProcNatl AcadSciUSA, 2003,100 ( 7 ) : 3983 -3988.
  • 2Christophe G, MinH H, Emmanuelle C J, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome [J]. Cell Stem Cell,2007,1 (5) :555 -567.
  • 3Stingl J, Eirew P, Ricketson I, et al. Purification and unique properties of mammary epithelial stem cells [ J ]. Nature ,2006,439 (7079) :993 - 997.
  • 4Patrawala L, CalhounT, Schneider-Broussard R, et al. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2 + and ABCG2 - cancer cells are similarly tumorigenic[J]. Cancer Res,2005,65 (14) :6207 -6219.
  • 5KIM M,TURNQU IST H,JACKSON J,et al. The multidrug resistance transporter ABCG2 ( breast cancer resistance p rotein 1 ) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells [ J ]. Clin Cancer Res ,2002,8( ! ) :22 -28.
  • 6Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties[J]. Cancer Res,2005, 65(13) :5506- 5511.
  • 7Li H Z, Yi T B, Wu Z Y. Suspension culture combined with chemotherapeutic agents for sorting of breast cancer stem cells[J]. BMC Cancer,2008,8:135.
  • 8Polyak R. Breast cancer origins and evolution [ J ]. J Clin Invest,2007,117:3155 - 3163.
  • 9Molyneux G, Regan J, Smalley M J. Mammary stem cells and breast cancer[ J ]. Cell Mol Life Sci ,2007 ( 1 ) : 13.
  • 10Sims A H, Howell A, Howell S J, et al. Origins of breast cancer subtypes and therapeutic imp lications [ J ]. Nature Clin Pract 0ncol,2007 (4) :516 - 525.

同被引文献40

  • 1尚文博,范忠林,马力.乳腺癌干细胞研究现状[J].临床肿瘤学杂志,2007,12(8):628-630. 被引量：1
  • 2Lengerke C, Fehm T, Kurth R, et al. Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma.BMC Cancer. 2011;11:42.
  • 3Debeb BG, Xu W, Mok H,et al. Differential radiosensitizing effect of valproic acid in differentiation versus self-renewal promoting culture conditions.lnt J Radiat Oncol Biol Phys. 2010;76(3):889-895.
  • 4Ricardo S, Vieira AF, Gerhard R, et al. Breast cancer stem cell markers CD44, CD24 and ALDHI: expression distribution within intrinsic molecular subtype.J Clin Pathol. 2011 ;64(11 ): 937-946.
  • 5Xing F, Saidou J, Watabe K.Cancer associated fibroblasts (CAFs) in tumor microenvironment.Front Biosci (Landmark Ed). 2010;15:166-179.
  • 6Polyak K, Kalluri R.The role of the microenvironment in mammary gland development and cancer.Cold Spring Harb Perspect Biol. 2010;2(11):a003244.
  • 7Korkaya H, Liu S, Wicha MS.Breast cancer,stem cells, cytokine networks, and the tumor microenvironment.J Clin Invest. 2011 ;121 (10):3804-3809.
  • 8Sneddon JB, Zhen HH, Montgomery K,et aI.Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.Proc Natl Acad Sci U S A. 2006; 103(40): 14842-14847.
  • 9RSmer AM, L0hr I, Klein A,et aI.Normal mammary fibroblasts induce reversion of the malignant phenotype in human primary breast cancer.Anticancer Res. 2013;33(4): 1525- 1536,.
  • 10AI-Hajj M, Wicha MS, Benito-Hernandez A,et aI.Prospective identification of tumorigenic breast cancer cells.Proc Natl Acad Sci U S A. 2003;100(7):3983-3988.

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重庆理工大学学报（自然科学）
2011年 第1期

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