血小板参数和凝血指标联合检测在肝硬化诊疗中的意义

Significance of combination detection of platelet parameters and coagulation indices in diagnosis and treatment of hepatic cirrhosis

目的了解肝硬化患者血小板参数和凝血指标含量变化,探讨其临床应用价值。方法检测57例肝硬化患者的血小板参数和凝血指标,并与120例健康对照组的血小板参数和凝血指标相比较。结果 (1)肝硬化组与健康对照组比较,血小板(PLT)、血小板比容(PCT)显著下降,血小板平均体积(MPV)、血小板分布宽度(PDW)显著增高;肝功能B、C级组与A级组比较,C级PLT、PCT下降显著,MPV、PDW显著升高。(2)肝硬化患者凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)均较健康对照组明显延长,纤维蛋白原(FIB)显著下降。结论肝硬化患者存在血小板及凝血功能异常,血小板参数和凝血指标可以反映肝病患者的肝损伤程度,为临床对病情判断、治疗及预后提供有价值的参考依据。

Objective To investigate the change of platelet parameters（PLT,PCT,MPV and PDW） and coagulation indices（PT,TT,APTT and FIB） in the patients with hepatic cirrhosis and to discuss their clinical value.Methods The platelet parameters and coagulation indices in 57 cases of hepatic cirrhosis and 120 cases as control were examined and analyzed.Results Compared with the control group,PLT and PCT in hepatic cirrhosis group were decreased evidently,while MPV and PDW were increased significantly.As the pathogenesis condition was more serious,PLT and PCT were lower and MPV and PDW were higher on C stage patients with hepatic cirrhosis than A stage ones.PT,TT and APTT in the patients were longer than those in the control group and FIB were decreased evidently,showing significant difference between two groups.Conclusion There is abnormality of platelet parameters and disturbance of coagulation indices in the patients with hepatic cirrhosis.Platelet parameters and coagulation indices may reflect the pathogenesis condition and damage degree of liver disease.