刺激兔杏仁体影响内膝体听觉神经元的ON-OFF反应

THE INHIBITORY EFFECT OF AMYGDALOID STIMULATION ON THE “ON OFF” RESPONSE OF MEDIAL GENICULATE BODY NEURONS IN RABBITS *

在２３只三碘季铵酚麻痹的新西兰兔上记录细胞外放电，观察短纯音诱发的内膝体神经元ｏｎｏｆ反应的特性及电刺激边缘系统杏仁外侧核（Ｌａｔｅｒａｌａｍｙｇｄａｌｏｉｄｎｕｃｌｅｕｓ，ＬＡｍ）对反应的影响。实验发现，内膝体神经元的ｏｎｏｆ反应与纯音刺激的强度、频率及作用时程有关；刺激ＬＡｍ，可以抑制ｏｎｏｆ反应，或是使ｏｎｏｆ反应放电构型发生变化。ｏｎｏｆ反应是神经元对声音信号作用时程及声音的起止进行编码的方式之一，ＬＡｍ对ｏｎｏｆ反应的影响表明，边缘系统杏仁体的活动可以调控听觉中枢对声音时间信息的编码。

Experiments were performed on 23 New Zealand rabbits immobilized with Flaxedil. The characteristics of on off responses of medial geniculate body (MGB) neurons to tone bursts of varying frequency, intensity and duration were affected by lateral amygdaloid nucleus (LAm) stimulation, which was in form of altering the pattern of discharge or complete suppression. The effect also varied with the changes of the interval between amygdaloid stimulation and the tone bursts. The results of the present work show that LAm could modulate temporal processing of auditory information.