丹参多酚酸盐治疗不稳定型心绞痛的疗效及其对一氧化氮和内皮素的影响

Effect of Salvianolate on unstable angina and its influence on NO and ET

目的观察丹参多酚酸盐治疗不稳定型心绞痛(UA)的疗效及其对血清一氧化氮(NO)和内皮素(ET)水平的影响。方法 60例患者随机分为治疗组和对照组各30例。对照组给予常规抗心绞痛治疗,治疗组在对照组治疗的基础上加用丹参多酚酸盐注射液。观察比较2组临床疗效、血清NO和ET水平及心电图改善和药物不良反应情况。结果 治疗组临床疗效、血清NO和ET水平及心电图改善情况均优于对照组,差异有统计学意义(P<0.05)。2组均未发生药物不良反应。结论丹参多酚酸盐可明显改善UA患者的临床症状和心电图ST-T改变,要提高血清NO水平的同时降低ET水平。

Objective To investigate the clinical effect of salvianolate on patients with unstable angina（UA）,as well as its influence on the level of nitric oxide（NO） and endothelin（ET） in blood serum.Methods 60 cases were randomly divided into treatment group and control group,30 cases of each.The control group was given traditional anti-angina treatment,while the treatment group based on the control group was added salvianolate injection.The clinical efficacy,level of NO and ET in serum,improvement situation of ECG,as well as the situation of adverse drug reaction（ADR） were observed.Restults The clinical efficacy,level of NO and ET,as well as the improvement situation of ECG of the treatment group were respectively better than those of the control group,and the differences were statistically significant（P0.05）.Both groups didn＇t happen serious ADR.Conclusion Salvianolate can significantly improved the symptoms and ECG ST-T segment of patients with UA,which can also decrease the level of ET and increase the level of NO.