以莫西沙星、埃索美拉唑镁为核心的三联疗法治疗一线、补救治疗失败的幽门螺杆菌感染的临床观察

Clinical effect of triple therapy with a core of Moxifloxacin and Nexium in the treatment of helicobacter pylori infection failed in being treated with first line or remedial treatment

目的观察以莫西沙星、埃索美拉唑镁肠溶片(耐信)为核心的三联疗法治疗一线、补救治疗失败的幽门螺杆菌(Hp)感染的临床疗效。方法 23例患者分为A组(一线治疗失败)12例和B组(补救治疗失败)13例。2组均给予莫西沙星+耐信+阿莫西林或克拉霉素三联疗法。观察2组Hp根治成功率及药物不良反应。结果 本组25例,Hp根治成功23例(92.0%)。其中,A组根治成功12例(100.0%),B组根治成功11例(84.6%),2组根治成功率比较差异无统计学意义(P>0.05)。仅1例治疗5d后出现恶心、纳差。结论以莫西沙星、耐信为核心的短程三联疗法治疗一线或补救治疗失败的Hp感染安全、经济、有效。

Objective To investigate the efficacy of triple therapy with a core of Moxifloxacin and Nexium in the treatment of helicobacter pylori（Hp） infection failed in being treated with first line or remedial treatment.Methods 25 cases were divided into A group（Failed in being treated with first line drug） of 12 and B group（Failed in remedial treatment） of 13.Both groups were given triple therapy of Moxifloxacin,Nexium and Amoxicillin or Clarithromycin.The Hp eradication rate and adverse drug reaction of 2 groups were observed.Results In this group,23 cases（92.0%）got successful Hp eradication,and the number in A and B group was 12 cases（100.0%） and 11 cases（84.6%）respectively,but there was no statistical significance between the Hp eradication rates of 2 groups（P0.05）.Only 1 case occurred vomiting and poor diet after being treated for 5 days.Conclusion Treating Hp infection failed in being treated with first line or remedial treatment with triple therapy with a core of Moxifloxacin and Nexium is safe,economic and effective.