激光心肌血管重建术长期实验观察

Long-term Experimental Observation of Transmyocardial Laser Revascularization

本实验旨在研究激光心肌血管重建术二种打孔方法对激光孔远期通畅的影响。方法３６只犬结扎左前降支获得急性心肌缺血动物模型，在缺血区随机分为Ａ、Ｂ二区，Ａ区采用“Ｍｉｒｈｏｓｅｉｎｉ”法，Ｂ区采用“滤波片”法打孔，术后４小时、０．５月、１个月、３个月、６个月取出心脏，通过病理学及微血管铸型判断激光孔是否通畅。结果术后６个月“Ｍｉｅｈｏｓｅｉｒｉ”法通畅率３８％，“滤波片”法７０％，术后３６个月激光孔仍通畅。结论“滤波片”法优于“Ｍｉｒｈｏｓｅｉｎｉ”法，二种打孔方法对心肌缺血有长期改善作用。

The purpose of this experiment is to study the long-term open effect of laser channels by two methods of transmyocardial laser revascularization.Method:The acute myocardial infarction was produced by ligation of LAD in 36 dogs.The ischemic zone was divided into A and B zones at random.A zone was irridiated by ‘Mirhoseini’ laser acquncture.B zone by ‘Filter wave slide'laser acquncture.The heatrs of dogs were acquired at 4 hour,0.5 month,1 month,3 month and 6 month after the operation.The patency of laser holes was identified by pathology and myocardial cast.Result:The open rate of Mirhoseini'is 38%,the rate of ‘Filler wave slide’ is 70% at 6 month after the operation.The laser holes is still clear 36 month later.Conclusion:Methos of Filter wave slide is superior to Mirhoseini's method.The two methods are all improvment for myocardial ischemi.