MCI及AD患者血清一氧化氮和超敏C反应蛋白的变化

Changes of Serum Nitric Oxide and High-sensitivity C-reactive Protein in Patients with MCI and AD

目的观察轻度认知障碍(MCI)及阿尔茨海默病(AD)患者一氧化氮(NO)及超敏C-反应蛋白(hs-CRP)的变化。方法用硝酸还原法及免疫散射比浊法检测正常老年人(对照组)、MCI患者(MCI组)及AD患者(AD组)血清中NO及hs-CRP的水平。结果与对照组比较,MCI与AD组NO水平明显降低(P<0.01),hs-CRP水平明显升高(P<0.01),MCI组与AD组NO水平及hs-CRP水平无明显差异(P>0.05)。结论 MCI及AD患者可能存在炎症反应诱导的内皮功能损伤。

[Objective] To observe the changes of nitric oxide and high-sensitivity C-reactive protein in patients with mild cognitive impairment（MCI） and Alzheimer disease（AD）.[Methods]The serum levels of nitric oxide （NO） and high-sensitivity C-reactive protein （hs-CRP） of normal elderly （the control group）,MCI patients （the MCI group） and AD patients （the AD group） were measured with nitric acid reduction and immune scatter turbidimetry.[Results]Compared with the control group,the NO level of MCI group and AD group decreased significantly （P0.01）,the hs-CRP level of two groups increased significantly （P0.01）.There was no significant difference in the levels of NO and hs-CRP between MCI group and AD group （P0.05）.[Conclusion]There may be the damage of endothelial function induced by chronic inflammation in patients with MCI and AD.