奥扎格雷联合醒脑静治疗老年急性氧化碳中毒疗效观察

Observation on curative effects of Xingnaojing injection in combination with Ozagrel on acute carbon monoxide poisoning

目的 观察奥扎格雷联合醒脑静治疗老年急性一氧化碳中毒的疗效.方法 根据入院时间的顺序,将68例老年一氧化碳中毒患者分成两组 2007年12月以前的住院患者设为对照组,共30例,予高压氧等常规治疗 2008年1月之后的住院患者设为治疗组,共38例,在对照组治疗的基础上加用奥扎格雷和醒脑静,观察两组24小时清醒率 并随访8周,观察两组迟发性脑病发生率.结果 治疗组患者24小内清醒率（84.2%）,高于对照组（66.7%）,两组间比较差异有显著性（p＜0.05） 治疗组8周后迟发性脑病发生率（13.1%）,较对照组（26.7%）明显减低,两组间比较差异有显著性（P＜0.05）.结论 奥扎格雷钠联合醒脑静治疗老年人急性一氧化碳,可促进患者苏醒,降低迟发性脑病的发生率.

Objective To observe the curative effect on using Xingnaojing injection combination with Ozagrel to treat the old patients with acute caron monoxide poisoning. Methods According to the order of admission time, divided sixty-eight old patients with actute carbon monoxide poisoning into the control group （Hospitalized before December 2007, 30 cases） and the treatment groups （Hospitalized after January 2008 , 38 cases）.The control group was treated with conventional treatment, which is hyperbaric oxygem treatment（HBO）. Couple with the treatment of the control group, the treatment group was added xingnaojing injection and ozagrel.The revival rates within 24 h of the two groups were compared.Maked a follow-up visit for 8 weeks, compared the DEACMP＇s （Delayed encephalopathy after acute carbon monoxide poisoning） formation rate betweent two groups.Results In the reatment group,the revival rate （84.2%） within 24h was higher than that （66.7%） in the control group. 8 weeks later, the DEACMP＇s formation rate （13.1%）decreases obviously.The differences were significant （P〈 0.05）.Conclusion On the basis of HBO and convertional treatment, using xinaojing injection and ozagrel to treat the old patients with actute carbon monoxide poisoning can obviously promote early revival,and cut the DEACMP＇s formation rate.