期刊文献+

三叶因子的研究进展 被引量:8

下载PDF
导出
摘要 三叶因子(trefoil factor,TFFs)是一类含一个或几个三叶因子结构域的分泌蛋白,该结构域是一段38或39个氨基酸的多肽,其中的6个半胱氨基以1-5,2-4,3-6配对的构型方式生成三对二硫键,从而形成典型的三叶状结构,此结构赋予TFFs家族蛋白耐酸、耐碱和耐蛋白酶水解的性质,同时也是其行使功能所必需的。
出处 《山西医科大学学报》 CAS 2011年第1期87-90,共4页 Journal of Shanxi Medical University
基金 973项目(2010CB529805) 国家基金委重点项目(30630014) 国家基金委面上项目(30570359) 中国科学院重要方向项目(KSCX2-YW-R-088)
  • 相关文献

参考文献14

  • 1Madsen J,Nielsen O,Tornoe I,et al.Tissue localization of human trefoil factors 1,2,and 3[J].J Histochem Cytochem,2007,55(5):505-513.
  • 2Farrell JJ,Taupin D,Koh TJ,et al.TFF2/SP-deficient mice show decreased gastric proliferation,increased acid secretion,and increased susceptibility to NSAID injury[J].J Clin Invest,2002,109(2):193-204.
  • 3Cheng AM,Morrison SW,Yang DX,et al.Energy dependence of restitution in the gastric mucosa[J].Am J Physiol Cell Physiol,2001,281(2):C430-438.
  • 4Taupin DR,Kinoshita K,Podolsky DK.Intestinal trefoil factor confers colonic epithelial resistance to apoptosis[J].Proc Natl Acad Sci U S A,2000,97(2):799-804.
  • 5Bossenmeyer-Pourie C,Kannan R,Ribieras S,et al.The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis[J].J Cell Biol,2002,157(5):761-770.
  • 6Yio X,Diamond M,Zhang JY,et al.Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways[J].Gastroenterology,2006,130(6):1696-1706.
  • 7Peterson AJ,Menheniott TR,O'Connor L,et al.H.pylori infection promotes methylates and silences TFF2 leading to gastric tumor development in mice and humans[J].Gastroenterology,2010,139(6):2005-2017.
  • 8Sun Y,Wu W,Wang L,et al.Overexpression of hTFF2 in the pET system and its in vitro pharmacological characterization[J].Biomed Pharmacother,2010,64(5):343-347.
  • 9Chan MW,Chan VY,Leung WK,et al.Anti-sense trefoil factor family-3 (intestinal trefoil factor) inhibits cell growth and induces chemosensitivity to adriamycin in human gastric cancer cells[J].Life Sci,2005,76(22):2581-2592.
  • 10Tu SP,Chi AL,Ai W,et al.p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells[J].Am J Physiol Gastrointest Liver Physiol,2009,297(2):G385-396.

同被引文献109

引证文献8

二级引证文献79

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部