抗磷脂综合征患者妊娠早期红细胞免疫黏附功能的实验观察

ANTIPHOSPHOLIPID SYNDROME DURING EARLY PREGNANCY RED CELL IMMUNE ADHERENCE FUNCTION IN EXPERIMENTAL OBSERVATIONS

目的检测、分析抗磷脂综合征(APS)患者妊娠早期红细胞免疫黏附功能。方法检测45例在妊娠早期首次确诊为APS患者的红细胞C3b受体花环率(RBC-C3bR)和红细胞免疫复合物花环率(RBC-ICR),并与40例非APS早期妊娠正常者和40例非妊娠健康妇女作对照。结果 APS患者妊娠早期RBC-C3bR水平明显低于非APS早期妊娠正常者和非妊娠健康妇女[(11.41±6.16)%vs(13.62±4.03)%、(15.14±3.12)%,p<0.05],RBC-ICR明显升高[(9.80±4.31)%vs(7.03±3.13)%、(5.40±2.38)%,p<0.01]。APS妊娠患者不同妊娠结局组的红细胞免疫黏附功能比较,异常结局组RBC-C3bR明显低于正常结局组[(10.12±3.94)%vs(12.15±6.01)%],RBC-ICR明显高于良性结局组[(11.0±3.11)%vs(9.01±4.3)%],差异均有统计学意义(p<0.05)。结论 APS患者妊娠早期的红细胞免疫黏附功能异常,其程度与妊娠结局有关,红细胞免疫黏附功能检测可作为APS患者妊娠期监测免疫状况、预测妊娠结局指标。

Objective Detection, analysis of antiphospholipid syndrome （APS） in patients with early pregnancy red cell immune adherence function. Methods Detection of early pregnancy for the first time in 45 patients diagnosed as APS red blood cell C3b receptor rosette （ RBC - C3bR） and immune complex rosette rate of red blood cells （ RBC - ICR） , and 40 eases of non - APS normal early pregnancy and 40 cases non - pregnant healthy women as controls. Results APS patients with early pregnancy RBC - C3bR non - APS was significantly lower than normal in early pregnancy and non - pregnant healthy women E （ 11.41± 6. 16 ） % vs （ 13.62 ± 4.03 ） %, （ 15.14 ± 3.12 ） % ,p 〈 0.05 ], RBC - ICR was significantly higher [ （ 9. 80 - 4. 31 ） % vs （ 7. 03 ±3.13 ） %, （ 5.40 ± 2. 38 ） %0, p 〈 0. 013. APS pregnancy, pregnancy outcome in patients with different group of immune adhesion function of red blood ceils compared to RBC - C3bR abnormal outcome group were significantly lower than the normal outcome group [ （ 10.12± 3.94） % vs （ 12. 15 ± 6. 01 ） % ] , RBC - ICR was significantly higher than benign outcome group [ （ 11.0 ± 3. 11 ） % vs （ 9. 01 ± 4. 3 ） % ], the differences were statistically significant （p 〈 0. 05 ）. Conclusion APS patients with early pregnancy red cell immune adherence function abnormalities, and pregnancy outcome related to its extent, red blood cell immune adherence function in patients with APS may be used as monitoring the immune status of preg- nancy, prediction of pregnancy outcomes.