以雷贝拉唑钠为主的三联疗法治疗72例胃溃疡患者的效果评价

Evaluation of the Effect of Rabeprazole-based Triple Therapy for 50 Patients with HP-positive Peptic Ulcer

目的探讨以雷贝拉唑钠为主的三联疗法治疗胃溃疡的效果。方法回顾性分析2009年3月至2010年2月采用雷贝拉唑+克拉霉素+阿莫西林三联疗法治疗幽门螺杆菌(HP)阳性的胃溃疡患者72例临床资料,并与奥美拉唑为主的对照组资料比较。结果观察组溃疡治愈率93.06%(67/72)明显高于对照组的80.0%(56/70),差异有统计学意义(P>0.05)。观察组HP根除率91.67%(66/72)与对照组的(90.0%)(63/70)比较,差异无统计学意义(P>0.05)。观察组不良反应4.17%(3/72)与对照组的(2.86%)(2/70)比较,差异无统计学意义(P>0.05)。观察组头晕2例、恶心1例;对照组头晕1例,腹泻1例,均在服药期间或疗程结束后自行消失,无1例终止服药。结论雷贝拉唑三联疗法具有HP根除率高、不良反应少、溃疡愈合迅速、疗程短等优点,是目前治疗HP阳性溃疡及根除HP较为理想的方案,值得临床进一步推广应用。

Objective To explore the effects of rabeprazole-based triple therapy for treatment peptic ulcer.Methods Retrospective analyzed of the clinical data of 72 case of peptic ulcer from March 2009 to February 2010 with rabeprazole ＋ amoxicillin ＋ clarithromycin triple therapy regimen as observation group,and compared with the omeprazole-based as the control group.Results Peptic ulcer cure rate of the observation group was 93.06%（67/72）,it was significantly higher than the control group 80.0%（56/70）,and the difference was statistically significant（P0.05）.HP eradication rate of the observation group was 91.67%（66/72） and control group 90.0%（63/70） the difference was not statistically significant（P0.05）.The adverse reactions observed 4.17%（3/72） and control group 2.86%（2/70） the difference was not statistically significant（P0.05）.2 cases of dizziness,1 case of nausea in the observation group;1 case of dizziness,1 case of diarrhea in the control group,all this were taken the drug during or after treatment and go away,no case of termination of medication.Conclusion rabeprazole triple therapy for HP eradication with high rate,fewer adverse reactions,rapid ulcer healing,short course,etc.,it is the ideal solution for treatment of ulcers and eradication of HP,and worth further clinical application.