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HER-2阳性晚期乳腺癌的治疗策略 被引量:5

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摘要 人表皮生长因子受体-2过表达型乳腺癌进展快,预后差。近年来,针对人表皮生长因子受体-2介导的信号传导途径开发了一系列分子靶向药物,特别是抗人表皮生长因子受体-2单克隆抗体曲妥珠单抗以及小分子酪氨酸激酶抑制药拉帕替尼及其临床应用,极大提高了人表皮生长因子受体-2阳性晚期乳腺癌的疗效,并改变了这类乳腺癌一线和二线治疗的临床实践。
作者 徐兵河
出处 《临床药物治疗杂志》 2011年第1期42-45,共4页 Clinical Medication Journal
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参考文献16

  • 1Wiechmann L,Sampson M,Stempel M.Presenting Features of Breast Cancer Differ by Molecular Subtype[J].Ann Surg Oncol,2009,16:2705-2710.
  • 2Carol A,Parise,Katrina R,et al.Breast Cancer Subtypes as De?ned by the Estrogen Receptor(ER),Progesterone Receptor(PR),and the Human Epidermal Growth Factor Receptor 2 (HER-2) among Women with Invasive Breast Cancer in California,1999 -2004[J].The Breast J,2009,15:593-602.
  • 3Hugh J,Hanson J,Cheang MC,et al.Breast cancer subtypes and response to docetaxel in node-positive breast cancer:use of an immunohistochemical definition in the BCIRG 001 trial[J].J Clin Onco1,2009,27:1168-1176.
  • 4龚芸,肖春花,付丽.美国临床肿瘤协会/美国病理医师学院乳腺癌HER2检测指南的解读及展望[J].中华病理学杂志,2009,38(12):795-799. 被引量:10
  • 5乳腺癌HER2检测指南(2009版)[J].中华病理学杂志,2009,38(12):836-840. 被引量:193
  • 6徐兵河.晚期乳腺癌的治疗原则与策略[J].中国医药导报,2010,7(6):6-8. 被引量:15
  • 7江泽飞,邵志敏,徐兵河.人表皮生长因子受体2阳性乳腺癌临床诊疗专家共识[J].中华肿瘤杂志,2010,32(2):158-160. 被引量:47
  • 8Slamon D,Leyland-Jones B,Shak S,et al.Addition of Herceptin(humanized anti -HER-2 antibody) to first line chemotherapy for HER-2overexpressing metastatic breast cancer(HER-2 +/MBC) markedly increases anticancer activity:a randomize,multinational controlled phase Ⅲ trial[J].Proc Am Soc Clin Oncol,1998,17:98a.
  • 9Norton L,Slamon D,Leyland-Jones B.Overall survival advantage to simultaneous chemotherapy plus the humanized anti-HER-2monoclonal antibody Herceptin in HER-2 overexpressing metastatic breast cancer[J].Proc Am Soc Clin Oncol,1999,18:127a.
  • 10Forbes JF,Pienkowski T,Valero V,et al.BCIRG 007:Randomized phase Ⅲ trial of trastuzumab plus docetaxel with or without carboplatin first line in HER-2 positive metastatic breast cancer (MBC)[J].Proc Am Soc Clin Oncol,2006 24:LBA516.

二级参考文献72

  • 1徐兵河,赵龙妹,袁芃,储大同.多西紫杉醇联合卡培他滨治疗蒽环类药物耐药性晚期乳腺癌的初步临床结果[J].癌症进展,2004,2(1):18-20. 被引量:24
  • 2徐兵河,赵龙妹,王佳玉,袁芃.泰索帝联合顺铂治疗31例蒽环类耐药性晚期乳腺癌疗效分析[J].中华肿瘤杂志,2006,28(6):471-473. 被引量:46
  • 3<乳腺癌HER2检测指南>编写组,霍临明.乳腺癌HER2检测指南[J].中华病理学杂志,2006,35(10):631-633. 被引量:165
  • 4步宏,郑杰.美国临床肿瘤学会/美国病理学医师学院乳腺癌HER2检测指南简介[J].中华病理学杂志,2007,36(7):496-497. 被引量:24
  • 5Piccart-Gebhart M J, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med,2005, 353 (16) :1659-1672.
  • 6Pritchard KI, Shepherd LE, O'Malley FP, et al. HER2 and responsiveness of breast cancer to adjuvant chemotherapy. N Engl J Med,2006,354(20) :2103-2111.
  • 7Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med, 2001,344 ( 1 Suppl 3 ) :783-792.
  • 8Baselga J, Carbonell X, Castaneda-Soto NJ, et al. Phase Ⅱ study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol, 2005,23 ( 10 ) :2162-2171.
  • 9Leyland-Jones B, Gelmon K, Ayoub JP, et al. Pharmacokinetics, safety, and efficacy of trastuzumab administered every three weeks in combination with paclitaxel. J Clin Oncol, 2003, 21 ( 21 ) : 3965-3971.
  • 10Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2- overexpressing metastatic breast cancer. J Clin Oncol, 2002,20 (3) :719-726.

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