肺心病患者糖代谢异常及其特点

Study on function of ancreatic islets in patients with chronic pulmonary heart disease

目的了解肺源性心脏病(简称肺心病)胰岛功能状态,分析肺心病糖代谢异常的原因。探讨肺心病急性期检测糖化血红蛋白、超敏C反应蛋白(hs-CRP)的临床价值。方法选择无糖尿病的肺心病急性加重期患者25例,进行胰岛素释放实验,血糖、糖化血红蛋白及hs-CRP检测,并与健康健康对照组比较。分析肺心病患者糖代谢异常及其特点。结果肺心病患者空腹和餐后2h血糖及胰岛素,以及糖化血红蛋白、hs-CRP检测结果与健康健康对照组比较,差异均有统计学意义。结论肺心病患者糖代谢异常,可能与胰岛素分泌不足和胰岛素活性降低有关。肺心病患者急性期糖化血红蛋白、hs-CRP水平与肺功能有显著相关性。因此,胰岛素、血糖、糖化血红蛋白及hs-CRP联合监测,有助于对肺心病发生、发展、预后作出准确判断,有重要的临床意义。

Objective To investigate function of pancreatic islets in patients with chronic pulmonary heart disease. To study the relationship between insulin,blood glucose, glycosylated hemoglobin and high sensitive C-reactive protein with chronic pulmonary heart disease. Methods 25 patients with chronic pulmonary heart disease were performed insulin,blood glucose,glyeosylated hemo globin and high sensitive C reactive protein test,and compared with the normal control. Results Blood glucose Glyc（ssylated hemo- globin, high sensitive C-reactive protein of chronic pulmonary heart disease was significantly higher than that of control insulin test of chronic pulmonary heart disease was significantly lower than that of control. Conclusion There is dysfunction of pancreatic islets in patients with chronic pulmonary heart disease. Glycosylated hemoglobin, high sensitive C-reactive protein of chronic pulmonary heart disease were significantly higher than that of control.